MAP- vs Cardiac Index–guided hemodynamic care during Whipple surgery
Official title: Comparison of the Effects of Mean Arterial Pressure-Based and Cardiac Index-Based Intraoperative Hemodynamic Management on Postoperative Renal Function in Patients Undergoing Pancreaticoduodenectomy: A Prospective Randomized Study
Run by Ankara Etlik City Hospital · NCT07603336 · Data updated 2026-11-12
This trial tests whether guiding intraoperative heart and blood flow with mean arterial pressure or with cardiac index works better to protect kidney function after Whipple surgery.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Ankara Etlik City Hospital Government |
| Locations | 1 site (Çankaya, Ankara) |
| Status | Recruiting |
| Started | May 27, 2026 |
| Main results expected | December 14, 2027 |
| Study ends | December 28, 2027 |
| Registry record updated | May 28, 2026 |
| Trial ID | NCT07603336 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults 18–80 years with ASA II–III status and normal baseline kidney function scheduled for Whipple surgery at the participating center.
✕Probably not a fit
Patients with severely reduced kidney function, very high surgical risk, or those outside the 18–80 age range may not benefit from the study interventions.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective randomized trial in adults undergoing pancreaticoduodenectomy. Participants are assigned to MAP-guided or cardiac index-guided hemodynamic management during surgery, with the aim of reducing postoperative kidney injury. The study compares two strategies that reflect different approaches to maintaining tissue perfusion and blood flow during a complex abdominal operation. The primary outcome is the change in serum creatinine from baseline to early postoperative timepoints. The trial is conducted at Ankara Etlik City Hospital and uses standard perioperative care alongside either MAP- or cardiac-index–based targets.
Why it matters
Potential benefit: If successful, the approach that better preserves renal function could lead to smoother recovery and fewer kidney-related complications after Whipple procedures.
How similar studies have gone: Prior work suggests hemodynamic targets influence renal outcomes in major surgery, but direct comparison of MAP versus cardiac index guidance in this context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18 to 80 years * Patients with American Society of Anesthesiologists physical status II-III * Patients with estimated glomerular filtration rate ≥60 mL/min/1.73 m² * Patients scheduled for pancreaticoduodenectomy / Whipple procedure * Patients who provide written informed consent Exclusion Criteria: * Patients younger than 18 years or older than 80 years * Patients with estimated glomerular filtration rate \<60 mL/min/1.73 m² * Patients with American Society of Anesthesiologists physical status other than II-III * Patients who refuse to participate in the study * Patients who withdraw consent at any stage of the study
Where it's running
-
Ankara Etlik City Hospital
Çankaya, Ankara, Turkey (Türkiye) Recruiting
Study contacts
- Study coordinator: Atakan Sezgi
- Email: kansezgi@gmail.com
- Phone: 00905323327000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
MAP- or Cardiac Index-Guided Hemodynamic Management in Colorectal Surgery
In people undergoing colorectal surgery, this study tests whether guiding intraoperative blood pressure with mean arterial pressure or with cardiac index leads to better kidney function after surgery.
-
Antiseptic-coated sutures to reduce pancreatic fistula risk after Whipple
This trial tests whether using antiseptic-coated sutures during a Whipple procedure reduces the chance of developing a pancreatic fistula within 90 days after surgery.
-
Ketamine and optic nerve swelling during procedural pain relief
This study tests whether giving ketamine for procedural pain relief changes the optic nerve sheath diameter in adults, using bedside ultrasound before and after dosing to see if intracranial pressure shifts differ by ketamine dose.
-
Analgesic effects of adding BiFeS block to adductor canal block after ACL reconstruction
This study tests whether adding a BiFeS block to the standard adductor canal block provides better pain relief after ACL reconstruction.
-
Surface topography and spine damage in radiographic axial spondyloarthritis
This study tests whether a radiation-free 3D surface topography method can reflect spine damage and sagittal balance in adults with radiographic axial spondyloarthritis.
-
Theta Burst Stimulation to Help Stroke Recovery (Upper and Lower Limbs)
This trial tests whether applying theta burst stimulation to the motor cortex, in combination with standard rehabilitation, helps people over 45 who recently had a first ischemic stroke recover arm and leg movement.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.