Ketamine and optic nerve swelling during procedural pain relief
Official title: Effect of Ketamine for Procedural Analgesia on Intracranial Pressure: A Prospective Assessment Using Optic Nerve Sheath Diameter
Run by Ankara Etlik City Hospital · NCT07916064 · Data updated 2026-11-12
This study tests whether giving ketamine for procedural pain relief changes the optic nerve sheath diameter in adults, using bedside ultrasound before and after dosing to see if intracranial pressure shifts differ by ketamine dose.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | Ankara Etlik City Hospital Government |
| Locations | 1 site (Ankara, Etlik) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | December 15, 2026 |
| Study ends | December 15, 2026 |
| Registry record updated | November 4, 2026 |
| Trial ID | NCT07916064 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who are hemodynamically stable and require intravenous ketamine for procedural analgesia in the emergency department.
✕Probably not a fit
Patients who are not receiving procedural ketamine or whose condition does not affect optic nerve sheath measurements may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, observational study conducted in the emergency department of Ankara Etlik City Hospital. Adult patients receiving intravenous ketamine for procedural analgesia are enrolled, with the dose chosen by the treating physician (0.5 mg/kg or 1 mg/kg). Researchers measure the optic nerve sheath diameter non-invasively by ocular ultrasonography before ketamine and at 2, 5, 15, and 30 minutes after administration, along with vital signs and pain scores. The study aims to determine if ketamine affects intracranial pressure as reflected in ONSD changes and whether the effect differs by dose. No treatment is altered by the study, and adverse events are recorded during the 30-minute observation window. Planned enrollment is 160 adults.
Why it matters
Potential benefit: If ketamine affects intracranial pressure, findings could help clinicians understand safety considerations during procedural analgesia.
How similar studies have gone: Similar noninvasive ONSD measurements have been used in other settings to explore intracranial dynamics, but this direct ketamine-dose comparison in procedural analgesia is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * Hemodynamically stable * Receiving intravenous ketamine for procedural analgesia for any clinical indication * Written and verbal informed consent Exclusion Criteria: * Pregnancy or suspected pregnancy * History of moderate or severe head trauma * History of cerebrovascular disease * Intracranial mass * Previous intracranial surgery * Signs of increased intracranial pressure * Chronic obstructive pulmonary disease * Hypercapnia * Porphyria * Liver failure * Chronic kidney disease * Cerebral palsy * Multiple sclerosis * Use of antidepressant medication * Optic neuritis * Globe rupture * Glaucoma * Use of an agent other than ketamine for procedural analgesia * Known allergy or intolerance to ketamine * Disorientation, inability to cooperate, or inability to communicate
Where it's running
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Ankara Etlik City Hospital
Ankara, Etlik, Turkey (Türkiye) Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.