MAO-B PET/CT imaging in Parkinson’s-related diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses 18F-FPyCO/SMBT-1 PET/CT to evaluate detection of lesions in adults with Parkinson’s-related diseases. Lesion uptake is quantified with SUVmax, and diagnostic metrics such as sensitivity, specificity, PPV, NPV, and accuracy are reported. Participants may undergo initial assessment or recurrence evaluation, with completed imaging guiding correlation to other diagnostic information. The study is conducted across multiple sites in China and involves collaboration between Tianjin Medical University and affiliated hospitals. No interventional therapy is administered; imaging serves a diagnostic biomarker purpose.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\- (i) adult patients (aged 18 years or order); (ii) patients with suspected or new diagnosed or previously treated PD (supporting evidence may include MRI, CT, tumor markers and pathology report); (iii) patients who had scheduled TSPO PET/CT scan; (iv) patients who were able to provide informed consent (signed by participant, parent or legal representative) and assent according to the guidelines of the Clinical Research Ethics Committee.

Exclusion Criteria:

* patients with non-malignant lesions; (ii) patients with pregnancy; (iii) the inability or unwillingness of the research participant, parent or legal representative to provide written informed consent.

Where it's running

• The First Affiliated Hospital of University of Science and Technology of China
  Hefei, Anhui, China Recruiting
• The Affiliated Hospital of Qingdao University
  Qingdao, Shandong, China Recruiting
• Tianjin Medical University General Hospital
  Tianjin, Tian, China Recruiting

Study contacts

• Study coordinator: Ying Wang, MD
• Email: macrossplusvoices@163.com
• Phone: +8618702292537

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• A look at why Lewy body conditions cause visual hallucinations

  This study tests brain‑imaging in people with Lewy body diseases who do or don’t experience visual hallucinations, and in healthy volunteers, to see how brain networks might create these images.

  Recruiting NYU Langone Health · New York, New York · NCT07849413

• Detecting phosphorylated alpha-synuclein in colon tissue to help diagnose Parkinson's

  This study will test whether routine colonoscopy tissue samples from adults with Parkinson's show phosphorylated alpha-synuclein, a protein linked to the disease.

  Recruiting CND Life Sciences · Portland, Oregon · NCT07204652

• Tributyrin for memory, thinking, and walking problems in Parkinson's disease

  This trial will test whether taking tributyrin three times a day for about 80–100 days helps memory, thinking, walking, and balance in adults with Parkinson's disease or Parkinson disease dementia, and will monitor safety.

  Recruiting Phase 1/2 University of Michigan · Ann Arbor, Michigan · NCT07154511

• Biobank for studying ALS and Alzheimer's diseases

  This study is collecting blood, skin samples, and health information from people to see how genetics might help us understand and find treatments for ALS and Alzheimer's disease.

  Recruiting New York Stem Cell Foundation Research Institute · New York, New York · NCT06203106

• Database for Parkinson's Disease and Related Disorders

  This study is creating a detailed database of information from people with Parkinson's disease to help researchers understand how the disease progresses and how different treatments work over time.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT04997642

• One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions

  A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07883720

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.