How older adults' brains use extra oxygen during surgery and whether that links to postoperative delirium

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, single-center study enrolling patients aged 65 or older having elective laparoscopic surgery under general anesthesia. During surgery, cerebral oxygenation and oxygen consumption responsiveness to increased oxygen supply will be monitored noninvasively using a forehead sensor (fNIRS/near-infrared oximetry). No changes to routine care are made; investigators will record intraoperative oxygenation patterns and any clinical data relevant to cerebral perfusion. Participants will be screened for postoperative delirium for up to three days after surgery using standard clinical assessments. The study will analyze whether impaired intraoperative cerebral oxygen consumption response is associated with higher rates of postoperative delirium.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing elective laparoscopic surgery under general anesthesia
* Age 65 years or older

Exclusion Criteria:

* Diagnosis of dementia or presence of delirium before surgery
* Loss of capacity to provide informed consent
* Moderate or severe cerebrovascular stenosis diagnosed before surgery
* Moderate or severe obstructive or restrictive pulmonary dysfunction identified on preoperative pulmonary function testing
* Requirement for supplemental oxygen therapy before surgery
* History of neurological disorders (e.g., Parkinson's disease, stroke) or prior brain surgery
* Severe hepatic dysfunction (AST or ALT \> 120 IU/L)
* Severe renal dysfunction (estimated GFR \< 15 mL/min/1.73 m²)
* Persistent severe hemodynamic instability (mean arterial pressure \< 60 mmHg)
* Skin conditions preventing placement of the forehead fNIRS sensor
* Combined surgical procedures performed concurrently
* Planned postoperative admission to the intensive care unit

Where it's running

• Seoul National University Bundang Hospital
  Seongnam-si, Gyeonggi-do, South Korea Recruiting

Study contacts

• Study coordinator: Soowon Lee, MD, PhD
• Email: soowonlee@snubh.org
• Phone: +82-31-787-7499

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.