How blood sugar control affects brain oxygen levels and recovery during urologic surgery
Official title: Effects of Intraoperative Near-Infrared Spectroscopy and Postoperative Recovery on Glycemic Control Levels in Patients With Diabetes Mellitus: A Prospective Study
Run by Ege University · NCT07491185 · Data updated 2026-11-12
This will see if long-term blood sugar control affects brain oxygen levels during anesthesia and recovery afterward in adults having elective urologic operations, including people with and without diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Ege University Academic / other |
| Locations | 1 site (Izmir) |
| Status | Recruiting |
| Started | November 1, 2025 |
| Main results expected | September 2026 |
| Study ends | March 2027 |
| Registry record updated | March 24, 2026 |
| Trial ID | NCT07491185 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (age ≥18) scheduled for elective urologic surgery under general anesthesia with a preoperative HbA1c available and ASA physical status I–III, including both diabetic and non-diabetic patients, are eligible.
✕Probably not a fit
Patients having emergency surgery, ASA >III, with prior cerebrovascular or neurological disease, or those who cannot provide reliable NIRS data are unlikely to benefit from the findings.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study groups adults undergoing elective urologic surgery by preoperative HbA1c into four categories, including non-diabetic controls. Intraoperative monitoring will include standard hemodynamic parameters and continuous bilateral regional cerebral oxygen saturation measured with near-infrared spectroscopy (NIRS). Researchers will compare intraoperative cerebral oxygenation and postoperative recovery scores across glycemic control groups. Analyses will explore whether higher HbA1c is associated with impaired cerebral perfusion during anesthesia and differences in early postoperative recovery.
Why it matters
Potential benefit: If a link is found, better long-term blood sugar control could help reduce intraoperative brain hypoxia and improve postoperative recovery strategies for surgical patients with diabetes.
How similar studies have gone: NIRS monitoring has been used successfully in other surgical populations to detect cerebral desaturation, but direct evidence linking chronic glycemic control to intraoperative cerebral oxygenation is limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Patients scheduled for elective urologic surgery under general anesthesia * ASA physical status I-III * Patients with diabetes mellitus or non-diabetic control patients * Availability of preoperative HbA1c measurement * Written informed consent obtained Exclusion Criteria: * Age \<18 years * ASA physical status \>III * Emergency surgery * History of cerebrovascular disease or neurological disorder * Previous brain or neurological surgery * Inability to communicate or refusal to participate * Intraoperative hemodynamic instability * Inadequate NIRS monitoring data
Where it's running
-
Ege University Faculty of Medicine Hospital
Izmir, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Nursen Karaca, Md — Ege University
- Study coordinator: Nursen Karaca, MD
- Email: dr.nursenkaraca@hotmail.com
- Phone: +902323902142
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.