Factors linked to in-hospital death in necrotizing soft tissue infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational multicenter cohort collects routine clinical and laboratory data from adults admitted with necrotizing soft tissue infections at four tertiary referral hospitals in Italy. Investigators will analyze information available at hospital admission to identify factors associated with in-hospital mortality. The cohort includes necrotizing fasciitis, Fournier's gangrene, and other NSTIs of the neck or trunk, and excludes patients transferred before outcome assessment or with missing primary outcome data. The aim is to produce practical early risk indicators that clinicians can use during initial evaluation to guide monitoring, resource allocation, and treatment intensity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Hospital admission with a diagnosis of necrotizing soft tissue infection, including: Necrotizing fasciitis, Fournier's gangrene, Necrotizing soft tissue infections involving the neck or trunk.

Exclusion Criteria:

* Age younger than 18 years
* Patients with non-necrotizing skin or soft tissue infections
* Patients transferred to another hospital before completion of treatment or outcome assessment
* Missing data for the primary outcome (in-hospital mortality)

Where it's running

• Cagliari University Hospital "Duilio Casula".
  Cagliari, Italy Recruiting
• Niguarda Hospital, Trauma team.
  Milan, Italy Recruiting
• San Gerardo Hospital, Department of Surgery
  Monza, Italy Recruiting
• Gemelli Hospital, Rome. Department of Surgery.
  Roma, Italy Recruiting

Study contacts

• Study coordinator: Mauro Podda, MD, FACS, Professor of Surgery
• Email: mauro.podda@unica.it
• Phone: +39 07051096571

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.