Malignant Colorectal Polyp Registry: What Happens After Early Colorectal Cancer is Removed
Official title: A Prospective Registry of Patients With Endoscopically Resected Malignant Colorectal Polyps (pT1 Colorectal Cancer): Risk of Residual and Recurrent Disease, and Patient and Provider Decision-Making
Run by Memorial Sloan Kettering Cancer Center · NCT07619079 · Data updated 2026-11-12
This registry follows adults who had a single early colorectal cancer polyp removed endoscopically to see how often cancer comes back or spreads and to understand how decisions about further surgery or surveillance are made.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Memorial Sloan Kettering Cancer Center Academic / other |
| Locations | 7 sites (Basking Ridge, New Jersey and 6 other locations) |
| Status | Recruiting |
| Started | May 19, 2026 |
| Main results expected | May 19, 2029 |
| Study ends | May 19, 2029 |
| Registry record updated | October 28, 2026 |
| Trial ID | NCT07619079 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults 18 years or older with a single malignant colorectal polyp (pT1) removed endoscopically and pathology confirmed within 90 days before enrollment.
✕Probably not a fit
Patients with multiple malignant polyps or those not meeting pathological criteria may not benefit from insights gained.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational registry collects medical records, pathology, imaging, and patient questionnaires from participants who had a malignant colorectal polyp (pT1) removed endoscopically. No additional treatment is given as part of the study; care decisions remain with patients and their doctors. Researchers will track outcomes over time and explore factors that influence treatment choices, including risk perception and preferences. Data will come from records, images, pathology slides, and patient-reported information to understand post-polypectomy trajectories.
Why it matters
Potential benefit: If successful, the registry could clarify post-polypectomy risk and inform shared decision-making between patients and clinicians.
How similar studies have gone: Similar observational work has provided valuable insights into post-polypectomy outcomes, though this registry adds patient-reported decision-making perspectives.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years or older * A single malignant colorectal polyp, defined as a colorectal adenocarcinoma invading the submucosa but not the muscularis propria (pT1), arising in an adenomatous or serrated polyp * Endoscopic resection of the malignant polyp by snare polypectomy, endoscopic mucosal resection (EMR), or endoscopic submucosal dissection (ESD) * Pathologic confirmation of the malignant polyp within 90 days before enrollment Exclusion Criteria: °More than one malignant polyp
Where it's running
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Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States Recruiting -
Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States Recruiting -
Memorial Sloan Kettering Bergen
Montvale, New Jersey, United States Recruiting -
Memorial Sloan Kettering Suffolk - Commack
Commack, New York, United States Recruiting -
Memorial Sloan Kettering Westchester
Harrison, New York, United States Recruiting -
Memorial Sloan Kettering Cancer Center
New York, New York, United States Recruiting
Show 1 more location
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Memorial Sloan Kettering Nassau
Uniondale, New York, United States Recruiting
Study contacts
- Principal investigator: Georgios Karagkounis, MD — Memorial Sloan Kettering Cancer Center
- Study coordinator: Georgios Karagkounis, MD
- Email: karagkog@mskcc.org
- Phone: 212-639-2269
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.