Lung Cancer Risk in Never-Smokers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study collects questionnaire data from women aged 40–74 who have never smoked, to explore risk factors for primary lung adenocarcinoma. Case participants must have pathologically confirmed lung adenocarcinoma, while control participants have no history or signs of lung cancer. Researchers will compare information between cases and controls to identify potential risk factors. Locations include Memorial Sloan Kettering sites in New Jersey, and the study is sponsored by Memorial Sloan Kettering Cancer Center.

Why it matters

Who can join: the full rules

Criteria:

* Female at birth
* Age 40-74 years
* No smoking history

  * Participants must be never-smokers, defined as having smoked \<100 cigarettes in their lifetime
* Documentation of disease - case patients

  o Case patients must have pathologically confirmed primary lung adenocarcinoma. New and prevalent cases will be eligible. Case patients with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.
* Criteria for control participants

  * Control participants must have no personal history of lung cancer, symptoms suspicious for lung cancer, or suspicious pulmonary nodules. Participants recruited as controls and found on imaging to have lesions suspicious for lung cancer will be excluded from analysis and followed prospectively. Data regarding these participants will be reported in a sensitivity analysis. Additional control participants will be recruited to ensure balanced age- and race-matched enrollment by frequency matching. Control participants with a history of prior non-lung cancer will be eligible for the study unless actively being diagnosed or treated for another form of cancer at the time of enrollment.

Where it's running

• Memorial Sloan Kettering Basking Ridge (All Protocol Activities)
  Basking Ridge, New Jersey, United States Recruiting
• Memorial Sloan Kettering Monmouth (All Protocol Activities)
  Middletown, New Jersey, United States Recruiting
• Memorial Sloan Kettering Bergen (All Protocol Activities)
  Montvale, New Jersey, United States Recruiting
• Memorial Sloan Kettering Suffolk - Commack (All Protocol Activities)
  Commack, New York, United States Recruiting
• Memorial Sloan Kettering Westchester (All Protocol Activities)
  Harrison, New York, United States Recruiting
• Memorial Sloan Kettering Cancer Center (All Protocol Activities)
  New York, New York, United States Recruiting

Study contacts

• Principal investigator: Alexis Chidi, MD, PhD — Memorial Sloan Kettering Cancer Center
• Study coordinator: Alexis Chidi, MD, PhD
• Email: arisestudy@mskcc.org
• Phone: (929) 829-0677

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.