LRRK2-linked Parkinson’s: Brain Chemistry and Function in PD Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study uses PET and MRI brain imaging along with cognitive and motor tests to compare PD patients with the LRRK2 mutation to those without the mutation. The goal is to see how brain chemical changes relate to motor and cognitive performance in these groups. Participants undergo imaging, neuropsychological testing, and questionnaires to characterize differences in cholinergic and other brain systems.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or Female, age 45 years and over.
2. Diagnosis of PD based on the United Kingdom Parkinson's Disease Society Brain Bank Diagnostic Research Criteria (Hughes et al., 1992).
3. Presence of LRRK2 mutation as confirmed by referral from UM Movement Disorders clinic, medical record review, or participation in the PDGENEration study.

Exclusion Criteria:

1. Evidence of atypical parkinsonism.
2. Contra-indications to MR imaging including but not limited to pacemakers, aneurysm clips, intraocular metal, cochlear implant, or severe claustrophobia.
3. Evidence of large vessel stroke or mass lesion on MRI.
4. Regular use of typical anti-cholinergic drugs or cholinesterase inhibitors.
5. History of deep brain stimulation surgery.
6. Pregnant or nursing.
7. Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory.
8. Cognitive impairment that results in the inability to give consent, as demonstrated by the Decision Making Capacity Tool.
9. Any other condition or criterion that would preclude safe and meaningful participation in the study.

Where it's running

• University of Michigan
  Ann Arbor, Michigan, United States Recruiting

Study contacts

• Principal investigator: Prabesh Kanel, PhD — University of Michigan
• Study coordinator: Nathan Alexander, BSc
• Email: natealex@med.umich.edu
• Phone: 734-998-6894

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.