Clinical trial Recruiting at 1 site Observational Ages 7 to 10

Long-term effects of silver diamine fluoride on the dentin-pulp area in primary teeth

Official title: Evaluation of the Long-term Effect of Silver Diamine Fluoride on the Dentin-Pulp Complex in Primary Teeth: A Histological Study

Run by Cairo University · NCT07586631 · Data updated 2026-11-12

This study looks at whether teeth previously treated with SDF plus resin-modified glass ionomer or with resin-modified glass ionomer alone stay healthy in the long term for children.

Quick facts

Study typeObservational
Ages7 Years to 10 Years
SexAll
Enrollment6 (estimated)
SponsorCairo University
Academic / other
Locations1 site (Cairo)
StatusRecruiting
StartedJanuary 29, 2026
Main results expectedMay 7, 2026
Study endsMay 15, 2026
Registry record updatedMay 14, 2026
Trial IDNCT07586631 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Children with primary teeth that have been treated for dentin caries without pulp involvement, specifically those who received SDF followed by RMGI or RMGI alone.

Probably not a fit

Teeth with signs of infection or other complications may not show additional benefit from retrospective analysis of past treatments.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will identify children with primary teeth that had dentin caries without pulp involvement and were previously treated with either SDF followed by resin-modified glass ionomer (RMGI) or RMGI alone. Parents and children will be informed about the detailed procedures and consent/assent obtained prior to any data or tooth use. Records from the Pediatric Dentistry and Dental Public Health department at Cairo University will be reviewed to describe long-term outcomes related to the dentin-pulp complex. No experimental interventions are described; the study analyzes existing treatment histories to understand durability and health of the treated teeth.

Why it matters

Potential benefit: Findings could clarify which prior treatment approach may be associated with better long-term integrity of the dentin-pulp complex in primary teeth.

How similar studies have gone: Previous observational work in this area has provided associations but causal conclusions remain limited; this study continues to explore long-term outcomes in a similar patient population.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Primary teeth that have previously been treated with either Silver Diamine Fluoride (SDF) followed by Resin Modified Glass Ionomer or Resin Modified Glass Ionomer alone.

Exclusion Criteria:

* Treated primary teeth with clinical or radiographic signs of infection

Where it's running

  • Faculty of Dentistry, Cairo University
    Cairo, Egypt
    Recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.