LMWH for Neonatal Outcomes in Isolated Oligohydramnios
Official title: Comparison of the Effect of Conventional Method Along With LMWH vs Conventional Method Alone in Improvement of Neonatal Outcomes in Pregnancies Complicated With Isolated Oligohydramnios in 2nd and 3rd Trimester.
Run by PAEC General Hospital, Islamabad · NCT07907731 · Data updated 2026-11-12
This trial tests whether adding a low-molecular-weight heparin shot to standard care helps babies born after oligohydramnios have better outcomes.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 20 Years to 45 Years |
| Sex | Women only |
| Enrollment | 106 (estimated) |
| Sponsor | PAEC General Hospital, Islamabad Academic / other |
| Locations | 1 site (Islamabad, Federal) |
| Status | Recruiting |
| Started | October 24, 2026 |
| Main results expected | January 25, 2027 |
| Study ends | January 30, 2027 |
| Registry record updated | October 30, 2026 |
| Trial ID | NCT07907731 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Pregnant women in the second or third trimester with isolated oligohydramnios (AFI < 8 cm), singleton pregnancy, intact membranes, and no hypertension, diabetes, or fetal abnormalities.
✕Probably not a fit
Women with comorbid conditions like hypertension or diabetes, multiple gestations, fetal abnormalities, or those already receiving treatment for oligohydramnios may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants are pregnant women with isolated oligohydramnios who are randomly assigned to receive standard care alone or standard care plus subcutaneous LMWH (40 mg) from 22 to 36 weeks. Standard care includes left-side rest, IV 5% dextrose, and low-dose aspirin from 22 to 34 weeks. All participants have weekly ultrasounds to monitor amniotic fluid and umbilical blood flow, with outcomes focused on preterm birth, birth weight, and live birth rate. The study is conducted at PAEC General Hospital in Islamabad, Pakistan, with ethical approval and predefined inclusion/exclusion criteria.
Why it matters
Potential benefit: If successful, the intervention could improve neonatal outcomes such as birth weight and rates of live birth in pregnancies affected by isolated oligohydramnios.
How similar studies have gone: Previous studies in similar areas have explored LMWH in obstetric settings, but results vary; this trial tests a specific regimen in isolated oligohydramnios.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Pregnant patients at in second and third trimester. 2. Isolated oligohydramnios with AFI \< 8 cm 3. Singelton pregnancy 4. Intact membranes Exclusion Criteria: 1. Hypertension 2. Diabetes 3. Fetal abnormalities 4. Who were already on any treatment for oligohydramnios 5. Patient having premature pre term rupture of membranes
Where it's running
-
Pakistan Atomic Energy Commission General Hospital
Islamabad, Federal, Pakistan Recruiting
Study contacts
- Study coordinator: Mehtab Aslam, MBBS
- Email: mehtabaslam182@gmail.com
- Phone: +92-332-8441418
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.