Lidocaine infusion for managing postoperative pain
Pharmacokinetic Profile of Lidocaine Given as a Weight-based Infusion for Postoperative Surgical Pain Control
This study is testing if giving lidocaine through an IV can help control pain after major surgeries for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Alberta Academic / other |
| Locations | 1 site (Edmonton, Alberta) |
| Trial ID | NCT05402293 on ClinicalTrials.gov |
What this trial studies
This study investigates the pharmacokinetic profile of lidocaine administered as a weight-based intravenous infusion for postoperative pain control in surgical patients. It aims to map serum lidocaine levels over time in a diverse population undergoing elective major surgeries. The study will involve blood sample collection to measure lidocaine concentrations and assess its effectiveness in pain management. The research is conducted at the University of Alberta Hospital over a duration of one year with a target enrollment of 40 participants.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-40 or over 75, classified as ASA class 1-3, scheduled for elective major surgeries where lidocaine infusion is appropriate.
Not a fit: Patients with a history of hypersensitivity to lidocaine or amide local anesthetics, or those requiring epidural or regional anesthesia techniques may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could provide an effective alternative to opioids for managing postoperative pain.
How similar studies have performed: Previous studies have shown that intravenous lidocaine infusions can effectively manage acute perioperative pain, suggesting a promising approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ASA class 1-3. Age 18-40 or \>75. - Scheduled for elective major surgery at the University of Alberta Hospital in which lidocaine infusion would be a good option as part of standard multimodal analgesia care Exclusion Criteria: * Contraindication / History of hypersensitivity to lidocaine or amide local anesthetics * Inability to give informed consent (illiteracy, \<7th grade education) * NYHA class III-IV heart disease * Planned epidural or regional anesthesia technique requiring local anesthetic
Where this trial is running
Edmonton, Alberta
- University of Alberta — Edmonton, Alberta, Canada (Recruiting)
Study contacts
- Principal investigator: James Green, MB BS — University of Alberta
- Study coordinator: James Green, MB BS
- Email: jgreen2@ualberta.ca
- Phone: 780-885-4792
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.