Lidocaine During Surgery to See If It Lowers Opioid Use in Kids with Arm Fractures

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, double-blind trial enrolling 90 children to compare intraoperative intravenous lidocaine infusion with placebo during surgical fixation of upper-extremity long-bone fractures. All participants receive standardized anesthesia and postoperative pain care, and researchers track opioid use and pain scores from intraop through recovery, with the main focus on total opioid use 60 minutes after arrival to PACU. Secondary outcomes include opioid use at later times, pain scores, PACU stay length, use of rescue antiemetics, and how infusion duration relates to outcomes. Eligibility targets children 3–18 years old weighing more than 10 kg undergoing fixation at Nemours Children’s Hospital, excluding those with certain medical or medication conditions that could affect results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients aged 3-18 years
* Patients \> 10 kg
* Patients who present to Nemours Children's Hospital - Delaware Valley (NCH-DE) for surgical fixation of upper extremity fractures from distal humerus to distal radius

Exclusion Criteria:

* Children \< 3 years or \> 18 years
* Patients with allergy to local anesthetics
* Patients who are eligible for an receive a peripheral nerve block
* Patients with multi-trauma or open fractures
* Patients with previous history of seizure disorder
* Patients with conduction abnormalities or cardiac arrhythmia requiring chronic treatment
* Patients on strong CYP450 inhibitors (fluvoxamine, erythromycin, ciprofloxacin, rifampin, allopurinol, ketoconazole, itraconazole)
* Patients with chronic kidney or liver dysfunction
* Patients with planned use of continuous infusion pain medications (opioids, ketamine, alpha-2- agonists)
* Patients with positive pregnancy test prior to surgery or nursing mothers
* Patients who parents decline enrollment

Where it's running

• Nemours Children's Hospital
  Wilmington, Delaware, United States Recruiting

Study contacts

• Study coordinator: Angela Snow, MD
• Email: angela.snow@nemours.org
• Phone: 302-824-1792

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Accuro XV ultrasound imaging for bone and fracture detection

  This study tests the Accuro XV ultrasound system to see if it can safely and comfortably provide clearer images of distal arm and leg injuries compared with standard imaging.

  Recruiting at 10 sites Rivanna Medical, Inc. · San Francisco, California and 9 other locations · NCT07853768

• Elastic nailing with Kirschner wires versus plate fixation for distal tibial fractures in adolescents

  This trial tests whether elastic stable intramedullary nailing with Kirschner wires works as well as plate fixation for fixing distal tibial fractures in kids aged 10 to 16.

  Recruiting Sohag University · Sohag, Sohag Governorate · NCT07783529

• 7-day oral antibiotic after surgery for people with diabetes and lower-leg fractures.

  This trial will test whether taking a 7-day antibiotic pill after surgery lowers wound infection risk in adults with poorly controlled diabetes who had surgery to fix a broken bone in the lower leg, ankle, or foot.

  Recruiting at 3 sites Phase 4 Texas Tech University Health Sciences Center, El Paso · Los Angeles, California and 2 other locations · NCT07561541

• Wrist Injury Strengthening Exercise added to usual care for improving pain and function after a wrist fracture

  This trial tests whether a therapist-guided strengthening program helps people 50 and older recover better from a wrist fracture than standard self-management advice.

  Recruiting University of Aarhus · Aarhus N · NCT07538323

• Animated video to reduce pain and anxiety during pin removal after supracondylar elbow fracture fixation

  We will try showing an animated video to children aged 4–12 during pin removal after supracondylar fracture fixation to see if it lowers pain and anxiety.

  Recruiting Liaquat National Hospital & Medical College · Karachi, Sindh · NCT07234396

• Comparing short and long fiberglass casts for children's forearm fractures

  This study tests whether a short fiberglass cast works just as well as a long fiberglass cast for kids with certain types of forearm fractures.

  Recruiting University Children's Hospital, Zurich · Zurich · NCT05156749

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.