Less invasive surfactant administration during high-flow oxygen in late preterm and early term infants

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study investigates whether administering surfactant via a less invasive technique (LISA) to infants receiving high-flow nasal cannula oxygen can lower the proportion of babies who require invasive mechanical ventilation within 72 hours of birth. Eligible participants are neonates born at 34+0 to 38+6 weeks of gestation who show respiratory distress and are on non-invasive respiratory support. The trial compares LISA during HFNC to standard non-invasive care without LISA, aiming to determine if the approach improves breathing support while reducing complications associated with ventilation. The investigation will monitor safety and clinical outcomes related to non-invasive versus invasive respiratory strategies in this specific gestational window.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Infants born at 34+0 to 38+6 weeks of gestation, requiring resuscitation at birth, but who achieve regular spontaneous breathing and have a heart rate over 100 beats per minute while receiving non-invasive support.
* Infants enrolled in the Surfon trial, born at 34+0 to 38+6 weeks of gestation, who are less than or equal to 24 hours old and exhibit signs of respiratory distress, defined as an FiO2 greater or equal to 0.30 but less than 0.45 needed to maintain an SpO2 greater than or equal to 92% or a clinically significant work of breathing regardless of the FiO2 and a clinical decision to provide non-invasive respiratory support.

Exclusion Criteria:

* Infants requiring intubation at birth
* Infants with severe congenital anomalies.

Where it's running

• King's College Hospital
  London, United Kingdom Recruiting

Study contacts

• Principal investigator: Theodore Dassios, PHD — King's College London
• Study coordinator: Eleanor Jeffreys, MBBS
• Email: eleanor.jeffreys@nhs.net
• Phone: +447519 974813

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.