Ketorolac vs corticosteroid injections for SI joint pain
Official title: Ultrasound Guided Sacroiliac Joint Injections With Ketorolac Versus Corticosteroid: A Prospective Non-inferiority Study
Run by McMaster University · NCT06081101 · Data updated 2026-11-12
This study tests whether ketorolac injections can relieve sacroiliac joint pain as well as corticosteroid injections in adults with chronic SI joint pain.
Quick facts
| Phase | Early Phase 1 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 20 (estimated) |
| Sponsor | McMaster University Academic / other |
| Locations | 1 site (Hamilton, Ontario) |
| Status | Recruiting |
| Started | March 1, 2025 |
| Main results expected | July 2028 |
| Study ends | July 2028 |
| Registry record updated | October 9, 2026 |
| Trial ID | NCT06081101 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with SI joint pain for at least 3 months and at least 3 positive SI joint tests on exam.
✕Probably not a fit
Patients with prior back surgery, radicular leg pain, discogenic or myofascial pain, or NSAID contraindications may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This early-phase study compares ultrasound-guided injections of ketorolac to methylprednisolone for sacroiliac joint pain. Participants must have had SI joint pain for at least three months and positive SI joint tests, and will be followed to 12 weeks after injection to assess pain relief. The goal is to see if ketorolac offers similar pain control at 2, 6, and 12 weeks, potentially reducing joint damage risk and cost. The trial is single-center, led by McMaster University at the Michael G. DeGroote Pain Clinic.
Why it matters
Potential benefit: If ketorolac proves as effective, patients may obtain similar pain relief with potentially lower risk of joint damage and lower treatment costs.
How similar studies have gone: Prior data in other joints suggest ketorolac can provide comparable pain relief to steroids, but SI joint data are limited and this study tests that applicability.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * SI joint pain for at least 3 months * Age greater than 18 * Must have at least 3 special tests positive for SI joint pain on physical exam Exclusion Criteria: * Previous back surgery * Radicular leg pain * Discogenic pain * Myofascial pain syndrome * Depression * Systemic infection or localized infection at anticipated needle entry sites * Cognitive impairment preventing informed consent or accurate collection of data * Patient allergic to medication used * NSAID contraindications including: * Gastrointestinal bleeds * Renal failure * Symptomatic congestive heart failure * Cirrhosis
Where it's running
-
Michael G. DeGroote Pain Clinic
Hamilton, Ontario, Canada Recruiting
Study contacts
- Study coordinator: Akil Siva, MD
- Email: akilsiva001@gmail.com
- Phone: 905-521-2100
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.