Brain wave‑guided noninvasive brain stimulation to help working memory in dementia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will use EEG to monitor brain waves related to working memory and apply time‑matched, noninvasive TMS to try to restore their alignment. The approach is tailored to each person’s brain patterns and aims to enhance short‑term memory and everyday thinking abilities. It is a proof‑of‑concept study to explore feasibility, safety, and potential signals of benefit in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals must be diagnosed with Alzheimer's Disease or related dementias by a clinician.
* Individuals must exhibit adequate oral communication skills and cognitive function sufficient to obtain a score above 10 on the MMSE
* Instructions will be delivered in English; therefore participants must demonstrate an understanding of instruction provided in English.
* Individuals must be at least 55 years or older

Exclusion Criteria:

* Contraindications to TMS; presence of a pacemaker, metal/electrical/magnetic implants not including titanium, known history of untreated or uncontrolled psychological disorders, pregnancy, history of seizure or diagnoses of epilepsy, are taking any prescription medications that increase the risk of seizure.
* Allergy to rubbing alcohol, which is needed to prepare electromyography for TMS

Where it's running

• Ivor Wynne Center
  Hamilton, Ontario, Canada Recruiting

Study contacts

• Study coordinator: Aimee Nelson
• Email: nelsonaj@mcmaster.ca
• Phone: (905) 525-9140

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.