Investigating rebound pain after nerve blocks in knee surgery
Pain Management After Total Knee Arthroplasty: Incidence and Outcomes of Rebound Pain
This study is trying to see if patients who get nerve blocks during knee surgery experience a sudden increase in pain afterward and how it affects their overall recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Konya City Hospital Academic / other |
| Locations | 1 site (Konya) |
| Trial ID | NCT06966011 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the occurrence and effects of rebound pain in patients who receive peripheral nerve blocks during total knee arthroplasty. It will track the incidence of rebound pain, defined as a sudden increase in pain after the nerve block wears off, along with secondary outcomes such as pain severity, use of additional pain relief, and overall patient satisfaction. Participants will be required to maintain a postoperative pain diary to document their experiences and outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 70 scheduled for elective unilateral total knee arthroplasty with planned peripheral nerve block.
Not a fit: Patients with severe comorbidities, allergies to local anesthetics, or those unable to participate in follow-up may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve pain management strategies for patients undergoing knee surgery.
How similar studies have performed: While similar studies on pain management techniques exist, the specific focus on rebound pain after peripheral nerve blocks in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age between 18 and 70 years * ASA physical status I to III * Scheduled for elective unilateral total knee arthroplasty under spinal anesthesia * Peripheral nerve block (PNB) planned as part of multimodal analgesia * Ability to understand and provide written informed consent * Willingness and ability to complete the postoperative pain diary Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetics * Contraindication to regional anesthesia * ASA physical status IV or higher * Neurological or psychiatric disorders interfering with study participation or pain reporting * Use of anticoagulants or presence of coagulopathy * Use of medications that may alter pain perception or rebound pain response * Local infection at the block site * Emergency surgeries * Inability or unwillingness to complete the postoperative pain diary or follow-up
Where this trial is running
Konya
- Konya City Hospital — Konya, Turkey (Recruiting)
Study contacts
- Study coordinator: Mahmut Tutar, MD
- Email: masatu42@gmail.com
- Phone: +905552723704
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.