Investigating inflammation in chronic lung disease and pulmonary hypertension
Inflammatory Profiling in Chronic Lung Disease
Ludwig Boltzmann Institute for Lung Vascular Research · NCT04654767
This study is trying to understand the role of inflammation in people with chronic lung diseases like COPD and IPF to see how it might be linked to pulmonary hypertension.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ludwig Boltzmann Institute for Lung Vascular Research (other) |
| Locations | 1 site (Vienna) |
| Trial ID | NCT04654767 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the inflammatory profiles in patients with chronic lung diseases, such as COPD and IPF, and their association with pulmonary hypertension. By utilizing techniques like flow cytometry, expression profiling, and histological analysis, the study will generate inflammatory data and correlate it with clinical outcomes. The goal is to identify common inflammatory mechanisms that may contribute to the development of pulmonary hypertension in these patients.
Who should consider this trial
Good fit: Ideal candidates include patients with COPD or IPF who are undergoing lung transplant and have associated pulmonary hypertension.
Not a fit: Patients without chronic lung diseases or those who do not meet the inclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better understanding and management of pulmonary hypertension in patients with chronic lung diseases.
How similar studies have performed: While there have been studies on pulmonary hypertension, this specific approach to inflammatory profiling in chronic lung disease is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients undergoing lung transplant with COPD or IPF, with associated PH * Signed informed consent Exclusion Criteria: * patients without written informed consent * Signs of any infection such as pneumonia, pulmonary tuberculosis or infections with pleural effusions.
Where this trial is running
Vienna
- Division of Thoracic Surgery, Department of Surgery, Medical University of Vienna — Vienna, Austria (RECRUITING)
Study contacts
- Principal investigator: Leigh Marsh — Ludwig Boltzmann Institute for Lung Vascular Research
- Study coordinator: Leigh Marsh
- Email: leigh.marsh@lvr.lbg.ac.at
- Phone: +4331638572911
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pulmonary Hypertension, Vascular Diseases, Lung Diseases, Respiratory Tract Diseases