Investigating factors that predict nicotine relapse in smokers
Identifying Biomarkers of Stress-induced Neurophysiological Changes and Emotion Regulation Deficits to Predict Relapse During Nicotine Abstinence
This study is testing how managing emotions and brain activity during stress can help smokers stay quit and avoid going back to smoking.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | University of Cyprus Academic / other |
| Locations | 1 site (Nicosia) |
| Trial ID | NCT06470321 on ClinicalTrials.gov |
What this trial studies
This study explores how emotion regulation abilities and stress-induced neural activity influence the likelihood of relapse in smokers trying to quit. Participants will undergo assessments of their emotional responses, neural activity using quantitative electroencephalography (qEEG), and stress reactions during a 24-hour period of nicotine abstinence. Following this, they will engage in a computerized smoking cessation program, with their abstinence monitored for six months. The study aims to identify predictors of successful smoking cessation and relapse.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-60 who smoke at least 10 cigarettes daily and intend to quit.
Not a fit: Patients with psychiatric disorders, unstable medical conditions, or those who are pregnant may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into personalized smoking cessation strategies that enhance long-term abstinence.
How similar studies have performed: Other studies have shown promise in using biomarkers and psychological factors to predict smoking cessation outcomes, suggesting this approach has potential.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18-60 years * Smoking at least 10 cigarettes daily for at least 2 years * Intention to quit smoking * Medication-free Exclusion Criteria: * Presence of psychiatric or medical treatment * Pregnancy * Current unstable medical illness * Recent (prior 6 months) drug or alcohol use disorder * Major Depression * Diagnosis of psychotic disorder
Where this trial is running
Nicosia
- Center for Applied Neuroscience — Nicosia, Cyprus (Recruiting)
Study contacts
- Study coordinator: Panos Zanos, Ph.D.
- Email: zanos.panos@ucy.ac.cy
- Phone: +35722892243
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.