Investigating cancer risk in patients with esophageal achalasia
Incidence and Risk Factors for Development of Epidermoid Carcinoma in Esophageal Achalasia
This study looks at whether people with esophageal achalasia are at a higher risk of developing a certain type of cancer and what factors might contribute to that risk.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 681 (estimated) |
| Sex | All |
| Sponsor | University of Bologna Academic / other |
| Locations | 1 site (Cotignola, RA) |
| Trial ID | NCT03546998 on ClinicalTrials.gov |
What this trial studies
This observational study aims to define the incidence and risk factors for epidermoid carcinoma development in patients with esophageal achalasia. A total of 681 patients diagnosed with achalasia have been followed since 1973, utilizing a prospective follow-up protocol approved by the local institutional review board. Clinical, radiological, and endoscopic data are collected and analyzed to understand the relationship between achalasia and cancer risk.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with primary esophageal achalasia confirmed through radiology, endoscopy, and manometry.
Not a fit: Patients with pseudoachalasia will not benefit from this study as they do not have the primary condition being investigated.
Why it matters
Potential benefit: If successful, this study could help identify at-risk patients and improve early detection strategies for epidermoid carcinoma in achalasia patients.
How similar studies have performed: While there is limited data on similar studies, the investigation of cancer risk in achalasia patients is a relatively novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * diagnosis of primary esophageal achalasia achieved by means of radiology, endoscopy and manometry Exclusion Criteria: * pseudoachalasia
Where this trial is running
Cotignola, RA
- Division of Thoracic Surgery Maria Cecilia Hospital — Cotignola, Ra, Italy (Recruiting)
Study contacts
- Principal investigator: Sandro Mattioli, MD — Department of Medical and Surgical Sciences-Alma Mater Studiorum-Università di Bologna
- Study coordinator: Sandro Mattioli, MD
- Email: sandro.mattioli@unibo.it
- Phone: 0039 0512144643
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.