Intravenous lidocaine with ropivacaine at the port sites for recovery after laparoscopic colorectal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this phase 3 randomized study, adults undergoing scheduled laparoscopic colorectal cancer surgery are assigned 1:1 to receive perioperative IV lidocaine infusion with port-site ropivacaine infiltration or port-site ropivacaine infiltration alone. The lidocaine is given as an induction bolus followed by a continuous infusion during surgery and stopped at closure. All patients receive standard anesthesia and multimodal postoperative pain control. The primary outcome is quality of recovery via QoR-15, with secondary measures including pain, opioid use, and systemic lidocaine and ropivacaine levels to monitor safety.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient undergoing scheduled colorectal cancer surgery via laparoscopy.
* Patient aged 18 years or older.
* Informed consent obtained and signed.
* Affiliation to a social security system.

Exclusion Criteria:

* Allergy or contraindication to lidocaine or ropivacaine.
* Allergy or contraindication to paracetamol, nefopam ketamine, propofol, dexamethasone, sufentanil, Celebrex or parecoxib, morphine derivatives, and colorectal surgery by laparotomy
* Colorectal surgery with a non-cancerous indication.
* Chronic preoperative pain (defined as persistent pain for more than 3 months).
* Preoperative use of opioids or opioid derivatives.
* Patients with psychiatric disorders.
* Patients for whom self-assessment of pain using a self-reported scale cannot be performed (non-communicative, non-French speaking, etc.).
* Pregnant or breastfeeding women.
* Patients under guardianship, curatorship, or legal protection.

Where it's running

• CHU Amiens
  Amiens, France Recruiting

Study contacts

• Study coordinator: Ottilie Trocheris - Fumery, MD
• Email: fumery.ottilie@chu-amiens.fr
• Phone: 33+322089108

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.