Remimazolam and Sevoflurane: How they work together during anesthesia
Official title: Response Surface Model Between Remimazolam and Sevoflurane; Comparison of the Minto and the Greco Model
Run by Pusan National University Yangsan Hospital · NCT07620782 · Data updated 2026-11-12
This study tests how remimazolam and sevoflurane interact during general anesthesia in adults undergoing laparoscopic surgery to see if their combined effect is stronger, the same, or weaker than expected.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 80 Years |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Pusan National University Yangsan Hospital Academic / other |
| Locations | 1 site (Yangsan) |
| Status | Recruiting |
| Started | May 15, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | December 31, 2027 |
| Registry record updated | June 2, 2026 |
| Trial ID | NCT07620782 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 20–80 years scheduled for elective laparoscopic surgery under general anesthesia (ASA I–II) at Pusan National University Yangsan Hospital.
✕Probably not a fit
Patients whose anesthetic depth is not influenced by the combination or whose conditions prevent reliable modeling may not benefit from the study insights.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective randomized study examines the pharmacodynamic interaction between remimazolam and sevoflurane using response surface modeling. It analyzes BIS values and predicted effect-site concentrations with NONMEM to characterize whether the combination is synergistic, additive, or infra-additive. Two established interaction models, the Minto model and the Greco model, will be applied to data from adult patients undergoing elective laparoscopic surgery. The goal is to clarify how these agents influence anesthetic depth and to improve dosing strategies.
Why it matters
Potential benefit: If successful, the findings could improve dosing guidance for combined remimazolam and sevoflurane use, potentially enhancing anesthesia safety and stability.
How similar studies have gone: Previous work has explored interactions between anesthetic agents, with response surface modeling emerging as a method to understand combos; this study applies that approach to a newer benzodiazepine and volatile anesthetic pairing.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged 20 to 80 years * Scheduled for elective surgery under general anesthesia at Pusan National University Yangsan Hospital * American Society of Anesthesiologists (ASA) physical status I or II * Able to provide written informed consent Exclusion Criteria: * Known allergy to remimazolam or sevoflurane * Renal, hepatic, neuromuscular, or neurological disease * Use of medications affecting the central nervous system * Chronic psychoactive drug use * Ischemic heart disease * Pregnant women
Where it's running
-
Pusan National University Yangsan Hospital
Yangsan, South Korea Recruiting
Study contacts
- Principal investigator: Hee Young Kim, MD, PhD — Pusan National University Yangsan Hospital, Yangsan, South Korea
- Study coordinator: Hee Young Kim, MD, PhD
- Email: anekhy@gmail.com
- Phone: 82-55-360-2129
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.