Superior hypogastric plexus block to improve recovery after laparoscopic colorectal cancer surgery
Official title: Superior Hypogastric Plexus Block for Early Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial
Run by Sixth Affiliated Hospital, Sun Yat-sen University · NCT07579780 · Data updated 2026-11-12
This will test whether adding a superior hypogastric plexus block helps adults having laparoscopic colorectal cancer surgery recover faster and have less pain.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 170 (estimated) |
| Sponsor | Sixth Affiliated Hospital, Sun Yat-sen University Academic / other |
| Locations | 1 site (Guangzhou, Guangdong) |
| Status | Recruiting |
| Started | December 15, 2025 |
| Main results expected | December 18, 2026 |
| Study ends | February 18, 2027 |
| Registry record updated | May 12, 2026 |
| Trial ID | NCT07579780 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with colorectal cancer scheduled for elective laparoscopic radical resection who are ASA class I–III and can give informed consent are the intended participants.
✕Probably not a fit
Patients with coagulation dysfunction, local or systemic infection, allergy to the block medications, inability to cooperate with the protocol, or those undergoing non-laparoscopic or emergency surgery are unlikely to be eligible or to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center, randomized, double-blind, placebo-controlled trial will enroll 170 patients undergoing elective laparoscopic radical resection for colorectal cancer and randomize them 1:1 to receive either a superior hypogastric plexus block or a placebo block. The primary outcome is the 15-item Quality of Recovery (QoR-15) score at 24 hours after surgery. Secondary outcomes include visceral pain scores at rest and with movement over 48 hours, opioid (morphine) consumption, time to first flatus, incidence of postoperative ileus, length of hospital stay, and inflammatory cytokine levels. The trial is designed to position the block within Enhanced Recovery After Surgery (ERAS) pathways for laparoscopic colorectal procedures.
Why it matters
Potential benefit: If successful, the block could reduce early postoperative visceral pain, lower opioid use, and improve short-term recovery and hospital throughput.
How similar studies have gone: Some smaller studies and regional anesthesia reports suggest superior hypogastric plexus or other pelvic blocks can reduce visceral pain, but high-quality randomized data specific to laparoscopic colorectal cancer surgery are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Able to provide informed consent. * Undergoing elective laparoscopic radical resection for colorectal cancer. * American Society of Anesthesiologists Physical Status (ASA) class I-III. Exclusion Criteria: * Allergy to block medication (s). * Coagulation dysfunction. * Local or systemic infection. * Unable to cooperate with the completion of the study protocol.
Where it's running
-
The Sixth Affiliated Hospital of Sun Yet-set University
Guangzhou, Guangdong, China Recruiting
Study contacts
- Study coordinator: Mengying Ding
- Email: 15170375679@163.com
- Phone: +86-15170375679
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.