Clinical trial Recruiting at 1 site Observational Ages 18 and up

Making a digital twin of the lung using photon-counting chest CT and clinical data

Official title: LUCE: LUng Cancer (r)Evolution

Run by Casa di Cura Dott. Pederzoli · NCT07517393 · Data updated 2026-11-12

This project will try to use adults' clinical records and non-contrast photon-counting chest CT scans to find lung nodules, tumors, and other lung diseases and to build a virtual 'digital twin' of the lung.

More Pulmonary Nodules trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1000 (estimated)
SponsorCasa di Cura Dott. Pederzoli
Academic / other
Locations1 site (Peschiera del Garda, Verona)
StatusRecruiting
Main results expectedMarch 2036
Study endsMarch 2036
Registry record updatedOctober 22, 2026
Trial IDNCT07517393 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults aged 18 or older who are scheduled for a non-contrast photon-counting chest CT at the study site and can give written informed consent are the intended participants.

Probably not a fit

People who do not have sufficient medical/anamnestic data, who will not undergo photon-counting chest CT, or who seek direct therapeutic treatment are unlikely to gain direct benefit from this observational project.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational project will collect and analyze past and future clinical, anamnestic, functional, and biological data from adults who undergo non-contrast photon-counting chest CT at the enrolling center. Physicians will decide on contrast use as needed, and enrolled patients will provide written informed consent. Collected data will be processed with artificial intelligence methods to attempt to create a virtual 'digital twin' of the lung and to track suspicious lung changes over time alongside clinical and laboratory parameters. Enrollment will run for 12 months at the single participating site in Peschiera del Garda, Verona.

Why it matters

Potential benefit: If successful, the work could help detect and track lung abnormalities earlier and enable virtual simulations that support safer, more personalized care decisions.

How similar studies have gone: AI-based analysis of CT scans and CT-based nodule detection have shown promise in research settings, but building a clinically useful 'digital twin' of the lung from photon-counting CT remains a novel and largely unproven approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Men or women aged ≥ 18 years who will perform a smdc photon count chest CT scan
* written informed consent.

Exclusion Criteria:

* Lack of information regarding anamnestic data
* any reason why the investigator deems the patient unenrollable in the practice.

Where it's running

  • Ospedale P. Pederzoli Casa di Cura Privata S.p.A.
    Peschiera del Garda, Verona, Italy
    Recruiting

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.