Intranasal insulin to reduce delirium after heart surgery with a heart-lung machine

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study focuses on adults undergoing elective cardiac surgery with cardiopulmonary bypass. Researchers will compare intranasal insulin at two dose levels to saline in terms of effects on blood sugar variability, insulin resistance, and the occurrence of postoperative delirium. The goal is to determine if brain-targeted insulin delivery can influence metabolic responses and improve postoperative cognitive outcomes. The study will monitor patients for delirium and collect data on glycemic fluctuations and insulin sensitivity during the perioperative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 18 years
* Scheduled for elective cardiac surgery with CPB

Exclusion Criteria:

* History of psychiatric disorders, neurological diseases, or mild cognitive impairment (MCI) (Mini-Cog score \< 3)
* Severe diabetes mellitus
* Participation in other interventional studies
* Coexistence of severe organic diseases
* Nasal deformities, nasal diseases, or history of nasal surgery

Where it's running

• Fujian Medical University Union Hospital
  Fuzhou, Fujian, China Recruiting

Study contacts

• Study coordinator: Yanjuan Lin
• Email: fjxhyjl@163.com
• Phone: +86 591 86218336

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.