Preoperative cognitive screening and postoperative delirium in older adults undergoing hip replacement
Official title: Orthopedic Procedures and Postoperative Delirium in the Czech Republic
Run by Tomas Bata Hospital, Czech Republic · NCT07432009 · Data updated 2026-11-12
This study tests whether a brief preoperative cognitive screen (ALBA) can predict delirium within 72 hours after hip replacement in older adults.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 65 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Tomas Bata Hospital, Czech Republic Academic / other |
| Locations | 7 sites (Brno and 6 other locations) |
| Status | Recruiting |
| Started | April 24, 2026 |
| Main results expected | December 31, 2029 |
| Study ends | March 31, 2030 |
| Registry record updated | July 9, 2026 |
| Trial ID | NCT07432009 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 65 or older undergoing elective total hip arthroplasty (general or regional anesthesia) with ASA I–III and ability to participate in testing.
✕Probably not a fit
Individuals with severe sensory impairments, active major psychiatric disorders, or other exclusion criteria may not benefit from the screening approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This multicenter, prospective observational study examines whether preoperative ALBA results correlate with the occurrence of postoperative delirium, as measured by CAM-ICU, in patients 65 and older undergoing elective total hip arthroplasty. It investigates associations with frailty, polypharmacy, comorbidities, anemia, anesthesia type, and intraoperative events. All participants receive standard perioperative care without additional procedures, and delirium is monitored for up to 72 hours post-surgery. The study builds on a prior pilot suggesting feasibility and potential predictive value of ALBA in this setting. Conducted across seven Czech hospitals, it aims to improve preoperative risk stratification and postoperative outcomes through routine cognitive screening.
Why it matters
Potential benefit: If successful, this approach could help identify patients at higher risk for delirium and guide targeted prevention and management strategies.
How similar studies have gone: Previous pilot work suggests ALBA may predict POD, but broader multicenter confirmation is needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 65 years * Elective total hip arthroplasty in general or regional anesthesia * ASA physical status I-III * Ability to understand and cooperate during testing; no severe sensory impairment (compensatory aids allowed) * Expected postoperative hospitalization in ICU, PACU, or standard ward Exclusion Criteria: * Glasgow Coma Scale ≤ 14 * Limited legal capacity * Active psychiatric disorder (e.g., psychotic disorder, bipolar disorder) * Active oncological disease * Chronic use of strong opioids * Premedication with anxiolytics or antipsychotics during preanesthetic evaluation * Acute reoperation within 3 months of primary surgery * Refusal to participate or withdrawal of consent
Where it's running
-
Tomas Bata Regional Hospital
Zlín, Czechia Recruiting -
University Hospital Brno - Bohunice
Brno, Czechia Not yet recruiting -
University Hospital Olomouc - Department of Anaesthesiology, Resuscitation and Intensive Care
Olomouc, Czechia Not yet recruiting -
University Hospital Ostrava - Department of Anaesthesiology, Resuscitation and Intensive Care
Ostrava, Czechia Not yet recruiting -
University Hospital Královské Vinohrady
Prague, Czechia Not yet recruiting -
University Hospital Motol
Prague, Czechia Not yet recruiting
Show 1 more location
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Vsetín Hospital
Vsetín, Czechia Not yet recruiting
Study contacts
- Study coordinator: Klára Nekvindová, M.D, Ph.D.
- Email: nekvindova.klara@gmail.com
- Phone: +420577 551 111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.