Improving prediction of coronary artery disease using arterial stiffness measurements

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate how device-estimated pulse wave velocity and machine learning techniques can enhance the prediction of symptomatic coronary artery disease in stable patients. It focuses on patients with suspected coronary artery disease who are undergoing coronary computer tomography angiography (CCTA). The study will compare traditional pre-test probability assessments with a new risk factor-weighted clinical likelihood method to improve risk estimation. By integrating non-invasive measurements of arterial stiffness, the study seeks to refine the decision-making process for further investigations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing coronary computer tomography angiography to investigate stable suspected symptomatic coronary artery disease.
* Age 30 to \<70 years of age.

Exclusion Criteria:

* Known coronary artery disease (prior myocardial infarction, percutaneous coronary intervention, coronary artery bypass graft or any angiographic evidence of coronary artery disease ≥50% lesion in a major epicardial vessel).
* Known significant cardiac (\> moderate valvular disease, heart failure with reduced ejection fraction, hypertrophic cardiomyopathy, or congenital heart disease), or pulmonary condition which could explain symptoms.
* Known ongoing atrial fibrillation/flutter.
* No Swedish social security number.
* Unable to provide written informed consent.

Where it's running

• Danderyd University Hospital
  Stockholm, Sweden Recruiting

Study contacts

• Principal investigator: Jonas Spaak, MD, PhD — Karolinska Institutet, Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Stockholm, Sweden
• Study coordinator: Henrik Hellqvist, MD
• Email: henrik.hellqvist@ki.se
• Phone: +46812355000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.