Improving functioning in veterans with OCD using therapy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of Exposure and Response Prevention (ERP) therapy in improving functioning, quality of life, and OCD symptoms among veterans diagnosed with OCD, including those with comorbid PTSD. Over four years, 160 veterans will be randomized to receive either ERP or a control condition of stress management training, with assessments conducted post-treatment and six months later. The study also includes a qualitative evaluation of veterans' perceptions of treatment impact and the implementation potential of ERP in VA mental health settings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Veterans having a primary diagnosis of Obsessive Compulsive Disorder (OCD)(50% of sample) and comorbid OCD and Post-traumatic stress disorder (PTSD) (50% of sample) who are receiving care from the Michael E. DeBakey VA Medical Center (MEDVAMC) in Houston, TX; the Ralph H. Johnson VA Medical Center in Charleston, SC; the VISN 20 Clinical Resource Hub which provides telehealth services to Washington, Oregon, and Alaska: the VISN 2 Clinical Resource Hub which provides telehealth services to New Jersey, New York, and northern Pennsylvania, and the VISN 6 Clinical Resource Hub which provides telehealth services to North Carolina and Virginia.
* Willingness to participate in Exposure and Response Prevention(ERP)

Exclusion Criteria:

* Significant cognitive impairment or conditions that threaten safety (current psychosis, mania, imminent suicidality including plan or intent, and treatment-interfering moderate to severe substance use).
* Potential participants taking psychotropic medications must be on a stable dose of these medications for at least 6 weeks prior to study enrollment.

Where it's running

• East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
  East Orange, New Jersey, United States Recruiting
• VA Western New York Healthcare System, Buffalo, NY
  Buffalo, New York, United States Recruiting
• VA NY Harbor Healthcare System, New York, NY
  New York, New York, United States Recruiting
• Northport VA Medical Center, Northport, NY
  Northport, New York, United States Recruiting
• James J. Peters VA Medical Center, Bronx, NY
  The Bronx, New York, United States Recruiting
• Asheville VA Medical Center, Asheville, NC
  Asheville, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Terri L. Fletcher, PhD — Michael E. DeBakey VA Medical Center, Houston, TX
• Study coordinator: Terri L Fletcher, PhD
• Email: Terri.Fletcher@va.gov
• Phone: (713) 440-4400

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.