Improving emergency care for sickle cell pain crises
Official title: Sickle Cell Improvement: Enhancing Care in the Emergency Department
Run by Medical College of Wisconsin · NCT05373771 · Data updated 2026-11-12
This study is testing a new way to help kids with sickle cell pain crises get the right pain relief faster when they go to the emergency room.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | Any age to 18 Years |
| Sex | All |
| Enrollment | 5328 (estimated) |
| Sponsor | Medical College of Wisconsin Academic / other |
| Locations | 1 site (Milwaukee, Wisconsin) |
| Status | Recruiting |
| Started | September 1, 2021 |
| Main results expected | August 31, 2026 |
| Study ends | August 31, 2027 |
| Registry record updated | August 14, 2023 |
| Trial ID | NCT05373771 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are children with sickle cell disease who present to the emergency department with uncomplicated pain crises and receive at least one opioid.
✕Probably not a fit
Patients experiencing complications such as acute chest syndrome, fever, priapism, or those with sickle cell trait may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to enhance the management of sickle cell disease (SCD) pain crises in emergency departments by implementing a structured care pathway. It focuses on ensuring timely administration of pain management as per established guidelines, which are often not followed due to various barriers, including structural racism. The intervention targets children with uncomplicated pain crises who receive opioids during their emergency visits. By addressing these issues, the study seeks to improve patient outcomes and reduce hospitalizations.
Why it matters
Potential benefit: If successful, this approach could significantly reduce pain and improve the quality of life for children suffering from sickle cell disease.
How similar studies have gone: Other studies have highlighted the importance of structured pain management protocols in emergency settings, suggesting potential success for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ED visit for uncomplicated pain crisis * Sickle cell disease * Receipt of at least one opioid Exclusion Criteria: * Acute chest syndrome * Fever \> 38.5 in the ED * priapism * sickle cell trait
Where it's running
-
Children's Wisconsin
Milwaukee, Wisconsin, United States Recruiting
Study contacts
- Principal investigator: David Brousseau, MD, MS — Nemours Children's Health
- Study coordinator: David Brousseau, MD, MS
- Email: david.brousseau@nemours.org
- Phone: (302) 651-4000
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.