Improving cognitive function in older adults using brain stimulation and digital tools
Accelerating Cognitive Gains From Digital Meditation With Noninvasive Brain Stimulation: A Pilot Study in MCI
NA · University of California, San Francisco · NCT06633952
This study is testing whether using brain stimulation together with digital brain training can help older adults with mild cognitive impairment think better and improve their quality of life.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 90 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | University of California, San Francisco (other) |
| Drugs / interventions | Radiation |
| Locations | 1 site (San Francisco, California) |
| Trial ID | NCT06633952 on ClinicalTrials.gov |
What this trial studies
This project aims to evaluate the feasibility and early effectiveness of combining non-invasive brain stimulation with digital cognitive interventions to enhance cognition and wellbeing in adults aged 60-85 with mild cognitive impairment (MCI). Participants will receive transcranial alternating current stimulation (tACS) alongside either the MediTrain or Worder digital cognitive training programs. The study will assess improvements in cognitive function and overall quality of life. The approach focuses on leveraging technology to address cognitive decline associated with aging.
Who should consider this trial
Good fit: Ideal candidates are adults aged 60-85 with mild cognitive impairment who are in good physical health and meet specific eligibility criteria.
Not a fit: Patients with neurological or psychiatric disorders, those on certain medications, or individuals with specific medical implants will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new methods for preventing cognitive decline and improving mental health in older adults.
How similar studies have performed: While the combination of brain stimulation and digital cognitive interventions is a relatively novel approach, similar studies have shown promising results in enhancing cognitive function.
Eligibility criteria
Show full inclusion / exclusion criteria
comfortably ambulatory healthy physical condition normal or corrected to normal visual auditory acuity fluency in spoken English Between 60-85 years old No neurological or psychiatric disorders No substance abuse Not taking anti-depressants Not taking anti-anxiety medication No history of seizures No color blindness No glaucoma No macular degeneration No amblyopia (lazy eye) No strabismus (cross eyed) Aneurysm clip(s) No Cardiac pacemaker No Implanted cardioverter defibrillator (ICD) No Electronic implant or device No Magnetically-activated implant or device No Neurostimulation system No Spinal cord stimulator No Internal electrodes or wires No Bone growth/bone fusion stimulator No Cochlear, otologic, or other ear implant No Insulin or other infusion pump No Implanted drug infusion device No type of prosthesis (eye, penile, etc.) No Heart valve prosthesis No Eyelid spring or wire No Artificial or prosthetic limb No Metallic stent, filter, or coil No Shunt (spinal or intraventricular) No Vascular access port and/or catheter No Radiation seeds or implants No Swan-Ganz or thermodilution catheter No Medication patch (Nicotine, Nitroglycerine) No metallic fragment or metallic foreign body in/on the body that can not be removed No Wire mesh implant No Tissue expander (e.g., breast) No Surgical staples, clips, or metallic sutures No Joint replacement (hip, knee, etc.) No Bone/joint pin, screw, nail, wire, plate, etc. No IUD, diaphragm, or pessary No Dentures or partial plates that can not be removed No Tattoo or permanent makeup No Body piercing jewelry No Claustrophobia
Where this trial is running
San Francisco, California
- University of California San Francisco — San Francisco, California, United States (RECRUITING)
Study contacts
- Principal investigator: David Ziegler, PhD — University of California, San Francisco
- Study coordinator: David Ziegler, PhD
- Email: david.ziegler@ucsf.edu
- Phone: 415-476-2164
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Aging, MCI, healthy aging, cognitive decline, prevention, brain stimulation, attention, memory