Impact of environmental exposures on tumor risk in SDHx mutation carriers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares SDHx mutation carriers who have developed SDHx-related tumors with those who have not. Past environmental and occupational exposures are collected via a telephone questionnaire, and a blood sample is offered. Cases and controls are matched by age and affected gene to explore the link between SDHi exposure and tumor risk. The lead sponsor is AP-HP, with collaboration from INSA, ANSES, and Centre Leon Berard, across several French centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Cases: SDHx mutation carriers diagnosed for a SDHx-related tumor
* Controls: SDHx mutation carriers with no SDHx-related tumor

Exclusion Criteria:

* Incapacity to exercise free and informed consent for the study
* Patient under tutorship or guardianship or legal safeguard

Where it's running

• Hôpital européen Georges Pompidou - APHP
  Paris, France Recruiting
• CHU d'Angers
  Angers, France Active not recruiting
• CHU Jean Minjoz Besançon
  Besançon, France Active not recruiting
• Hôpital Louis Pradel
  Bron, France Active not recruiting
• CHU de Caen
  Caen, France Active not recruiting
• Hôpital Michalon - CHU Grenoble
  Grenoble, France Active not recruiting

Study contacts

• Study coordinator: Alexandre Buffet, MD, PhD
• Email: alexandre.buffet@aphp.fr
• Phone: 33-1-56093879

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.