Impact of Bariatric Surgery on Ramipril Absorption
Bariatric Surgery and Pharmacokinetics of Ramipril: BAR-MEDS Ramipril
This study is testing how bariatric surgery affects the way the body absorbs the heart medication ramipril in people who have had gastric bypass or sleeve gastrectomy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 12 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Norwegian University of Science and Technology Academic / other |
| Locations | 1 site (Trondheim) |
| Trial ID | NCT03440177 on ClinicalTrials.gov |
What this trial studies
This observational study investigates how bariatric surgery, specifically gastric bypass and sleeve gastrectomy, affects the pharmacokinetics of the medication ramipril. It aims to understand changes in gastric pH, gastric emptying time, and gastrointestinal transit-time that may influence the biological availability of this drug. By examining these factors, the study seeks to provide insights into medication management for patients undergoing these surgical procedures.
Who should consider this trial
Good fit: Ideal candidates are Norwegian citizens preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway.
Not a fit: Patients who have previously undergone resections in the gastrointestinal tract may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved medication management for patients undergoing bariatric surgery, enhancing the effectiveness of ramipril.
How similar studies have performed: While there is limited research on this specific topic, similar studies have shown that bariatric surgery can significantly alter drug pharmacokinetics, suggesting potential for meaningful findings.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
Where this trial is running
Trondheim
- St. Olavs University Hospital — Trondheim, Norway (Recruiting)
Study contacts
- Principal investigator: Magnus Strømmen, MSc — St. Olavs Hospital
- Study coordinator: Magnus Strømmen, MSc
- Email: magnus.strommen@stolav.no
- Phone: 0047 72829970
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.