Impact of Bariatric Surgery on Female Sexual Function and Hormones

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows about 40 women aged 18–45 with severe obesity who undergo primary bariatric surgery at Cairo University. It compares each participant’s sexual function, hormone levels, mood, quality of life, body image, and partner sexual health before surgery and six months afterward. Measurements include FSFI, total and free testosterone, estradiol, SHBG, and calculated free androgen index, along with Beck Depression and Anxiety inventories and quality-of-life assessments. The study aims to understand potential links between hormonal changes, psychological well-being, and sexual function after weight loss. Sleeve gastrectomy or Roux-en-Y gastric bypass are the planned interventions, with participants limited to those who have a stable partner relationship and can complete Arabic-language questionnaires.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Female gender
* Age 18-45 years (childbearing period)
* Body Mass Index (BMI) ≥40 kg/m² or ≥35 kg/m² with obesity-related comorbidities, meeting international criteria for bariatric surgery
* Scheduled for primary bariatric surgery (sleeve gastrectomy or Roux-en-Y gastric bypass)
* Presence of a stable, sexually active intimate partner relationship
* Sexually active
* Willingness to participate and provide informed consent
* Ability to complete Arabic-language questionnaires

Exclusion Criteria:

* Women who are not sexually active
* Post-menopausal women (amenorrhea ≥12 months without other cause)
* Current pregnancy or lactation
* History of medication use that can interfere with sexual function, including:
* Antidepressants
* Antipsychotics/psychotropic drugs
* Beta-blockers
* Spironolactone
* Hormonal contraceptives (unless stable for ≥3 months and continued throughout study)
* Hormone replacement therapy
* Major uncontrolled medical conditions:
* Chronic heavy smoker (smoking index ≥400 pack-years)
* History of pelvic floor surgery or gynecological malignancy
* Partner with known erectile dysfunction or use of erectile dysfunction medications
* Previous bariatric surgery (revisional procedures)
* Inability or unwillingness to provide informed consent

Where it's running

• Faculty of Medicine Cairo University
  Cairo, Al-Manial Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed Eid Aziz, Lecturer
• Email: Ahmed-eid@kasralainy.edu.eg
• Phone: +201127060844

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.