Gut stool tests after sleeve vs gastric bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study compares stool test results from adults undergoing two common bariatric procedures: sleeve gastrectomy and gastric bypass (including mini gastric bypass and Roux-en-Y). Participants provide stool samples before surgery and at 6 months after, allowing researchers to look for signs of maldigestion, undigested food, and gut inflammation. The goal is to see if the type of surgery leads to different stool findings and whether fecal markers relate to weight loss and diabetes improvement. The study uses routine, inexpensive stool analyses to generate real-world insights on post-surgical gut health and function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Male and female patients aged 18 to 60 years
* Body Mass Index (BMI) ≥ 40 kg/m², OR BMI ≥ 35 kg/m² with at least one obesity-related comorbidity (type 2 diabetes, hypertension, dyslipidemia, osteoarthritis, obstructive sleep apnea)
* Patients scheduled for primary laparoscopic bariatric surgery (either SG or Gastric Bypass \[MGB or RYGB\]) at Kasr Al-Ainy University Hospitals
* Provision of written informed consent

Exclusion Criteria:

* Age \< 18 years or \> 60 years
* Previous bariatric surgery or major gastrointestinal surgery (gastric, intestinal, or colorectal resection)
* Chronic kidney disease (eGFR \< 60 mL/min/1.73m²) or previous renal transplant
* Chronic liver disease (cirrhosis, chronic hepatitis) or liver failure
* Chronic inflammatory bowel disease (Crohn's disease, ulcerative colitis), celiac disease, or chronic pancreatitis
* Active malignancy or history of chemotherapy/radiotherapy in the past 5 years
* Pregnancy or breastfeeding
* Chronic alcohol abuse or substance abuse
* Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to stool sample collection (to avoid confounding effects on gut flora)
* Acute gastrointestinal infection at the time of sample collection

Where it's running

• Faculty of Medicine Cairo University
  Cairo, Al-Manial Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed Eid Aziz, Lecturer
• Email: Ahmed-eid@kasralainy.edu.eg
• Phone: +201127060844

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.