Identifying Biomarkers for Effective Deep Brain Stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to enhance the effectiveness of deep brain stimulation (DBS) therapy by identifying objective biomarkers through direct electrophysiological recordings of brain activity in a cognitive context. It focuses on patients with severe neurological and psychiatric conditions who require DBS, utilizing data collected during the surgical implantation process to optimize individualized treatment parameters. The goal is to establish predictive criteria that can accelerate the customization of DBS therapy for better patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patient
* Patient suffering from a pathology requiring treatment with deep brain stimulation: neurological disease (e.g.: Parkinson Disease, Essential Tremors, dystonia, epilepsy, etc.) or psychiatric disease (e.g.: Obsessive Compulsive Disorder, depression, eating disorders, etc.).
* Patient capable of understanding the study procedures and completing the self-questionnaires in French
* Patient informed and having signed the informed consent form

Exclusion Criteria:

* Contraindications to DBS, neurosurgery or anesthesia
* Patients with significant hemorrhagic or infectious risks
* Patient unable to perform the neurocognitive or sensorimotor tests
* Patient who is not a beneficiary of a social security system.

Where it's running

• Groupe Hospitalo-Universitaire Paris Psychiatrie et Neurosciences, Paris
  Paris, France Recruiting
• Grenoble-Alpes Hospital Center
  Grenoble, France Not yet recruiting

Study contacts

• Study coordinator: Philippe Domenech, Professor, MD, PhD
• Email: philippe.domenech@ghu-paris.fr
• Phone: 0033(0)149812201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.