Identifying a proteomic pattern for diagnosing chronic thromboembolic pulmonary hypertension
Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension : PROTEO-CTEPH Study.
This study is trying to find a specific pattern in blood proteins to help doctors better diagnose chronic thromboembolic pulmonary hypertension in patients who have symptoms like shortness of breath.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire de Saint Etienne Academic / other |
| Locations | 1 site (Saint-Etienne) |
| Trial ID | NCT05340023 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify a specific proteomic pattern in patients suspected of having Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Patients with symptoms such as persistent dyspnea and perfusion defects will undergo blood sampling to analyze their proteomic profiles. The study seeks to improve diagnostic accuracy for CTEPH, which is often misdiagnosed due to limitations in current imaging techniques like transthoracic echocardiography. By establishing a reliable proteomic signature, the study hopes to enhance patient evaluation and management.
Who should consider this trial
Good fit: Ideal candidates include patients with suspected CTEPH who exhibit symptoms and have undergone relevant imaging studies.
Not a fit: Patients with a normal perfusion lung scan or those under legal guardianship may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate and timely diagnoses of CTEPH, improving patient outcomes.
How similar studies have performed: While the approach of using proteomic patterns for diagnosis is innovative, similar studies have shown promise in other conditions, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations) * Patients who require a right heart catheterization. * Patient affiliated or entitled to a social security plan * Patient having received informed information about the study informed about the study Exclusion Criteria: * Patient with a normal perfusion lung scan * Person under legal guardianship
Where this trial is running
Saint-Etienne
- CHU de SAINT-ETIENNE — Saint-Etienne, France (Recruiting)
Study contacts
- Principal investigator: Laurent BERTOLETTI, PhD — Centre Hospitalier Universitaire de Saint Etienne
- Study coordinator: Laurent BERTOLETTI, MD PhD
- Email: laurent.bertoletti@chu-st-etienne.fr
- Phone: (0)477127770
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.