Identifying a proteomic pattern for diagnosing chronic thromboembolic pulmonary hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify a specific proteomic pattern in patients suspected of having Chronic Thromboembolic Pulmonary Hypertension (CTEPH). Patients with symptoms such as persistent dyspnea and perfusion defects will undergo blood sampling to analyze their proteomic profiles. The study seeks to improve diagnostic accuracy for CTEPH, which is often misdiagnosed due to limitations in current imaging techniques like transthoracic echocardiography. By establishing a reliable proteomic signature, the study hopes to enhance patient evaluation and management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
* Patients who require a right heart catheterization.
* Patient affiliated or entitled to a social security plan
* Patient having received informed information about the study informed about the study

Exclusion Criteria:

* Patient with a normal perfusion lung scan
* Person under legal guardianship

Where it's running

• CHU de SAINT-ETIENNE
  Saint-Etienne, France Recruiting

Study contacts

• Principal investigator: Laurent BERTOLETTI, PhD — Centre Hospitalier Universitaire de Saint Etienne
• Study coordinator: Laurent BERTOLETTI, MD PhD
• Email: laurent.bertoletti@chu-st-etienne.fr
• Phone: (0)477127770

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Pulmonary Embolism Registry from Emergency Care to Long-Term Follow-Up

  This registry follows adults with acute pulmonary embolism to see how care is given in the real world and what happens over time.

  Recruiting at 16 sites Azienda Ospedaliero-Universitaria Careggi · Bagno a Ripoli, Tuscany and 15 other locations · NCT07855679

• Nailfold Capillaroscopy in Pulmonary Hypertension

  This study tests whether nailfold capillary scans correlate with invasive lung blood pressure measurements and whether these patterns change with PH treatment.

  Recruiting University of Glasgow · Clydebank, West Dunbartonshire · NCT07768644

• How pulmonary endarterectomy affects confidence in managing chronic thromboembolic pulmonary hypertension

  This project will see if pulmonary endarterectomy helps people with chronic thromboembolic pulmonary hypertension feel more confident managing their condition.

  Recruiting Damascus University · Damascus, Rif-dimashq Governorate · NCT07272798

• Registry of people with chronic thromboembolic pulmonary hypertension in Russia

  This registry collects health, history, and treatment information from people in Russia with chronic thromboembolic pulmonary hypertension to see which factors relate to their prognosis.

  Recruiting National Medical Research Center for Cardiology, Ministry of Health of Russian Federation · Moscow · NCT07254078

• Effects of stopping riociguat on heart function in patients with CTEPH

  This study is testing how stopping the medication riociguat affects heart function in patients with inoperable CTEPH who have had balloon pulmonary angioplasty.

  Recruiting at 3 sites Phase 3 Beijing Chao Yang Hospital · Beijing, China and 2 other locations · NCT06922240

• Switching from Sildenafil to Riociguat for CTEPH Patients

  This study is testing if switching from sildenafil to riociguat can help people with Chronic Thromboembolic Pulmonary Hypertension feel better after they’ve already had balloon pulmonary angioplasty.

  Recruiting Phase 4 Chinese University of Hong Kong · Hong Kong · NCT06715280

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.