Identify people at high risk of coronary heart disease using retinal images and blood markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study combines retrospective and prospective data from CAD patients to build a comprehensive database that includes demographics, lab tests, coronary angiography, retinal vessel metrics, and multi-omics data. Artificial intelligence will quantify retinal vessels and help develop models to identify and predict CAD. Targeted LC-MS/MS assays will measure CAD-related biomarkers in stored baseline samples, and results will be integrated with clinical and imaging data to create a risk-stratification model. Participants will be followed over time for cardiovascular events to validate the model.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Older than 18 years
* Symptoms suggestive of myocardial ischemia or the presence of multiple cardiovascular disease risk factors
* Underwent coronary angiography during hospitalization
* Underwent blood sample collection during hospitalization
* Underwent bilateral color fundus photography during hospitalization
* Availability of complete clinical data

Exclusion Criteria:

* History of heart transplantation or other solid-organ transplantation
* Severe heart failure, defined as New York Heart Association (NYHA) functional class IV or left ventricular ejection fraction (LVEF) ≤20%
* History of severe congenital heart disease, valvular heart disease, myocardial disease, pericardial disease, or aortic dissection
* Pregnancy, breastfeeding, or plans to become pregnant during the study period
* Progressive life-threatening disease
* History of alcohol or drug abuse
* Current treatment for a psychiatric disorder
* Current receipt of radiotherapy or chemotherapy for a malignant tumor
* Acute or chronic infectious disease
* Severe hepatic insufficiency, renal insufficiency, thyroid disease and autoimmune disease
* Life expectancy of less than 5 years
* Ophthalmic diseases affecting the retinal vasculature or optic disc structure, including retinal artery occlusion, retinal vein occlusion, glaucoma, or congenital optic disc abnormalities
* Color fundus photographs of insufficient quality because of severe ocular media opacity

Where it's running

• Beijing Hospital
  Beijing, Beijing Municipality, China Recruiting
• Beijing Friendship Hospital, Capital Medical University
  Beijing, Beijing Municipality, China Not yet recruiting
• Beijing Haidian Hospital
  Beijing, Beijing Municipality, China Completed

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.