How redox balance during heart surgery with bypass might predict short-term outcomes
Official title: Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome
Run by University Hospital, Toulouse · NCT06840327 · Data updated 2026-11-12
This observational study in adults having heart surgery with bypass tests whether redox balance markers can predict short-term post-operative outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 120 (estimated) |
| Sponsor | University Hospital, Toulouse Academic / other |
| Locations | 1 site (Toulouse) |
| Status | Recruiting |
| Started | October 7, 2025 |
| Main results expected | October 2027 |
| Study ends | October 2027 |
| Registry record updated | June 29, 2026 |
| Trial ID | NCT06840327 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing scheduled bypass surgery with saphenous vein harvesting, able to understand and consent to the protocol.
✕Probably not a fit
Emergency surgery patients, pregnant or breastfeeding women, and individuals unable to provide informed consent or under protective/legal restrictions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, single-center observational study investigates whether biomarkers of redox balance, including the tissue and blood levels of oxidants and reductants, can forecast short-term complications after cardiac surgery with extracorporeal circulation. The study collects blood and tissue samples, along with functional walking tests, to explore associations between redox potential and post-operative outcomes. It aims to identify a potential biomarker that reflects how patients respond to the stress of cardiopulmonary bypass. Results could help with risk stratification and early intervention planning in this surgical population.
Why it matters
Potential benefit: If successful, the findings could help predict which patients are at higher risk of complications after cardiac surgery and guide perioperative management.
How similar studies have gone: Previous work suggests redox-related markers may relate to post-surgical outcomes, but this specific approach is exploratory in a monocentric setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Patients over 18 years of age Scheduled cardiac surgery patients undergoing bypass surgery with saphenous vein harvesting. Patients able to understand the protocol; Patients able to express non-opposition to participating in the study Patients affiliated to a social security system or equivalent. Exclusion Criteria: Emergency surgery patients. Pregnant or breast-feeding women. Patients deprived of their freedom or under legal protective measures.
Where it's running
-
UHToulouse
Toulouse, France Recruiting
Study contacts
- Study coordinator: François LABASTE, MD-PH
- Email: labaste.f@chu-toulouse.fr
- Phone: 05 61 32 28 22
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.