Clinical trial Recruiting at 1 site Observational Ages 18 and up

How redox balance during heart surgery with bypass might predict short-term outcomes

Official title: Impact of VARIation of OXYdo-reduction Potential in Cardiac Surgery on Post-operative Outcome

Run by University Hospital, Toulouse · NCT06840327 · Data updated 2026-11-12

This observational study in adults having heart surgery with bypass tests whether redox balance markers can predict short-term post-operative outcomes.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment120 (estimated)
SponsorUniversity Hospital, Toulouse
Academic / other
Locations1 site (Toulouse)
StatusRecruiting
StartedOctober 7, 2025
Main results expectedOctober 2027
Study endsOctober 2027
Registry record updatedJune 29, 2026
Trial IDNCT06840327 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults undergoing scheduled bypass surgery with saphenous vein harvesting, able to understand and consent to the protocol.

Probably not a fit

Emergency surgery patients, pregnant or breastfeeding women, and individuals unable to provide informed consent or under protective/legal restrictions may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center observational study investigates whether biomarkers of redox balance, including the tissue and blood levels of oxidants and reductants, can forecast short-term complications after cardiac surgery with extracorporeal circulation. The study collects blood and tissue samples, along with functional walking tests, to explore associations between redox potential and post-operative outcomes. It aims to identify a potential biomarker that reflects how patients respond to the stress of cardiopulmonary bypass. Results could help with risk stratification and early intervention planning in this surgical population.

Why it matters

Potential benefit: If successful, the findings could help predict which patients are at higher risk of complications after cardiac surgery and guide perioperative management.

How similar studies have gone: Previous work suggests redox-related markers may relate to post-surgical outcomes, but this specific approach is exploratory in a monocentric setting.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Patients over 18 years of age Scheduled cardiac surgery patients undergoing bypass surgery with saphenous vein harvesting.

Patients able to understand the protocol; Patients able to express non-opposition to participating in the study Patients affiliated to a social security system or equivalent.

Exclusion Criteria:

Emergency surgery patients. Pregnant or breast-feeding women. Patients deprived of their freedom or under legal protective measures.

Where it's running

  • UHToulouse
    Toulouse, France
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.