Evaluating protein levels in children undergoing cardiac surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study focuses on children aged 0 to 17 years who are undergoing cardiac surgery with extracorporeal circulation (ECC). It aims to evaluate the levels of blood and cardiac protein O-GlcNAcylation, which may play a role in the inflammatory response and complications associated with ECC. The study seeks to understand how these protein levels correlate with postoperative outcomes, particularly in relation to low cardiac output syndrome and other complications. By identifying potential biomarkers, the research could pave the way for new therapeutic strategies to improve patient outcomes following cardiac surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age from 0 to 17 years at the time of sampling
* Children undergoing CEC for cardiac surgery
* Signed bio-collection consent

Exclusion Criteria:

* Children with an infection
* Children with fever
* Children with an immune deficiency
* Children with autoimmune disease
* Children with metabolic disease
* Children with haematological diseases
* Children with a genetic disease
* Unsigned consent
* Refusal by parents or child

Where it's running

• Nantes University Hospital
  Nantes, France Recruiting

Study contacts

• Study coordinator: Manon Denis
• Email: manon.denis-med@chu-nantes.fr
• Phone: +33 2 40 08 34 83

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.