Evaluating protein levels in children undergoing cardiac surgery
Evaluation of the Levels of O-GlcNAcylation of Cardiac and Blood Proteins in Paediatric Cardiac Surgery and Identification of Therapeutic Targets
Nantes University Hospital · NCT06754709
This study is testing how certain protein levels in children having heart surgery might relate to their recovery and complications after the operation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 300 (estimated) |
| Ages | N/A to 17 Years |
| Sex | All |
| Sponsor | Nantes University Hospital (other) |
| Locations | 1 site (Nantes) |
| Trial ID | NCT06754709 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on children aged 0 to 17 years who are undergoing cardiac surgery with extracorporeal circulation (ECC). It aims to evaluate the levels of blood and cardiac protein O-GlcNAcylation, which may play a role in the inflammatory response and complications associated with ECC. The study seeks to understand how these protein levels correlate with postoperative outcomes, particularly in relation to low cardiac output syndrome and other complications. By identifying potential biomarkers, the research could pave the way for new therapeutic strategies to improve patient outcomes following cardiac surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 0 to 17 years who are scheduled for cardiac surgery involving extracorporeal circulation.
Not a fit: Patients with infections, fever, immune deficiencies, autoimmune diseases, metabolic diseases, hematological diseases, or genetic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for children undergoing cardiac surgery, potentially reducing complications and enhancing recovery.
How similar studies have performed: While the specific approach of evaluating O-GlcNAcylation in this context may be novel, studies on inflammatory responses and cardiac surgery complications have shown varying degrees of success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age from 0 to 17 years at the time of sampling * Children undergoing CEC for cardiac surgery * Signed bio-collection consent Exclusion Criteria: * Children with an infection * Children with fever * Children with an immune deficiency * Children with autoimmune disease * Children with metabolic disease * Children with haematological diseases * Children with a genetic disease * Unsigned consent * Refusal by parents or child
Where this trial is running
Nantes
- Nantes University Hospital — Nantes, France (RECRUITING)
Study contacts
- Study coordinator: Manon Denis
- Email: manon.denis-med@chu-nantes.fr
- Phone: +33 2 40 08 34 83
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cardiac Surgery, Extracorporeal Circulation, Complications, Metabolism, Low Cardiac Output, cardiac surgery, extracorporeal circulation, metabolism