How obstructive sleep apnea affects thinking and memory

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, observational longitudinal cohort of 100 adults newly diagnosed with obstructive sleep apnea who have no chronic diseases other than overweight or obesity and are not on chronic medications. Participants will undergo multidimensional testing including standardized neuropsychological batteries, neuroimaging, vascular and metabolic measures, and molecular biomarkers to map physiological and pathophysiological processes linked to cognition. A subgroup with moderate to severe OSA who are prescribed positive airway pressure (PAP) therapy will be followed longitudinally to observe treatment-related changes. The design aims to reduce confounding by enrolling treatment-naive, otherwise-healthy adults and is conducted at Comenius University and University Hospital Bratislava in Slovakia.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Informed consent.
2. Age 18 - 65 years.
3. Newly diagnosed OSA according to the criteria of the American Academy of Sleep Medicine Guidelines (overnight PSG with an AHI ≥5 events per hour, hypopneas defined by ≥ 10 seconds of airflow reduction accompanied by ≥ 3% desaturation or an arousal).
4. Able to accomplish relevant tests and follow-up.

Exclusion Criteria:

1. History of any chronic disease other than overweight and obesity.
2. Severe psychiatric condition that could affect cognitive functions.
3. Chronic use of medication or nicotine that may affect the study results.
4. Prior neuropsychological assessment less than 6 months before the start of the research.
5. Prior therapy for OSA (i.e., CPAP, upper airway surgery, or oral appliance).
6. Motor or sensory deficits that would significantly complicate test administration.
7. Patients who do not have Slovak as their native language actively used in daily communication.
8. Considered by the study team as not suitable for enrollment based on clinical judgment.

Where it's running

• 1st Department of Neurology, Faculty of Medicine, Comenius University and University Hospital Bratislava, Slovakia
  Bratislava, Slovakia Recruiting

Study contacts

• Study coordinator: Branislav Kollar, prof. MD PhD. MPH.
• Email: b.kollar.md@gmail.com
• Phone: +421 948 334 417

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.