How knee alignment changes after total hip replacement
Official title: Evaluation of Knee Phenotype Following Total Hip Arthroplasty :A Prospective Cohort Study
Run by Assiut University · NCT07597538 · Data updated 2026-11-12
This study tests whether knee alignment changes after a hip replacement in people with hip problems.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 500 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut, Asyut Governorate) |
| Status | Recruiting |
| Started | February 1, 2026 |
| Main results expected | February 1, 2028 |
| Study ends | August 1, 2028 |
| Registry record updated | May 19, 2026 |
| Trial ID | NCT07597538 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults scheduled for primary unilateral total hip arthroplasty with hip pathology indicated for THA, who can provide informed consent and complete pre/postoperative radiographs.
✕Probably not a fit
Patients who do not complete pre- or post-operative radiographs or who have prior ipsilateral hip or knee surgery or neuromuscular disorders affecting alignment may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this prospective cohort study, researchers will measure knee alignment before and after total hip arthroplasty using full-length radiographs to see how knee biomechanics change after the hip procedure. Coronal plane alignment parameters will be quantified to characterize any shifts in knee phenotype following surgery. The findings may help understand the biomechanical impact of THA on the knee and inform future care.
Why it matters
Potential benefit: If successful, the study could clarify how knee alignment may improve or worsen after hip replacement, guiding patient counseling and follow-up.
How similar studies have gone: Similar radiographic studies have explored knee–hip interactions, but this specific phenotype change after THA is less established and more exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * patients scheduled for primary unilateral total hip arthroplasty * patient with hip joint pathology indicated for THA ( osteoarthritis ) * ability to provide informed consent * availability for pre and post- operative radiographic follow-up Exclusion Criteria: * refusal to participate or withdraw consent * incomplete radiographic data or loss to follow up * previous surgery on the ipsilateral hip or knee * patients with neuromuscular disorders affecting alignment
Where it's running
-
Department of orthopedic surgery faculty of medicine assiut university
Asyut, Asyut Governorate, Egypt Recruiting
Study contacts
- Principal investigator: mohamed kamal abdelnasser, MD professor orthopedic — faculty of medicine assiut univerisity
- Study coordinator: nader ahmed sayed, MD (resident)
- Email: Nader.17289651@med.aun.edu.eg
- Phone: +201029975354
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.