Clinical trial Recruiting at 1 site Observational

How knee alignment changes after total hip replacement

Official title: Evaluation of Knee Phenotype Following Total Hip Arthroplasty :A Prospective Cohort Study

Run by Assiut University · NCT07597538 · Data updated 2026-11-12

This study tests whether knee alignment changes after a hip replacement in people with hip problems.

Quick facts

Study typeObservational
SexAll
Enrollment500 (estimated)
SponsorAssiut University
Academic / other
Locations1 site (Asyut, Asyut Governorate)
StatusRecruiting
StartedFebruary 1, 2026
Main results expectedFebruary 1, 2028
Study endsAugust 1, 2028
Registry record updatedMay 19, 2026
Trial IDNCT07597538 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults scheduled for primary unilateral total hip arthroplasty with hip pathology indicated for THA, who can provide informed consent and complete pre/postoperative radiographs.

Probably not a fit

Patients who do not complete pre- or post-operative radiographs or who have prior ipsilateral hip or knee surgery or neuromuscular disorders affecting alignment may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this prospective cohort study, researchers will measure knee alignment before and after total hip arthroplasty using full-length radiographs to see how knee biomechanics change after the hip procedure. Coronal plane alignment parameters will be quantified to characterize any shifts in knee phenotype following surgery. The findings may help understand the biomechanical impact of THA on the knee and inform future care.

Why it matters

Potential benefit: If successful, the study could clarify how knee alignment may improve or worsen after hip replacement, guiding patient counseling and follow-up.

How similar studies have gone: Similar radiographic studies have explored knee–hip interactions, but this specific phenotype change after THA is less established and more exploratory.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* patients scheduled for primary unilateral total hip arthroplasty
* patient with hip joint pathology indicated for THA ( osteoarthritis )
* ability to provide informed consent
* availability for pre and post- operative radiographic follow-up

Exclusion Criteria:

* refusal to participate or withdraw consent
* incomplete radiographic data or loss to follow up
* previous surgery on the ipsilateral hip or knee
* patients with neuromuscular disorders affecting alignment

Where it's running

  • Department of orthopedic surgery faculty of medicine assiut university
    Asyut, Asyut Governorate, Egypt
    Recruiting

Study contacts

  • Principal investigator: mohamed kamal abdelnasser, MD professor orthopedic — faculty of medicine assiut univerisity
  • Study coordinator: nader ahmed sayed, MD (resident)
  • Email: Nader.17289651@med.aun.edu.eg
  • Phone: +201029975354

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.