How GFAP and UCH-L1 Blood Tests Could Help Personalize Care for Older Recurrent Fallers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The BACHUS study enrolls patients aged 75 and older who are admitted after repeated falls to a geriatric unit. Researchers will measure GFAP and UCH-L1 in whole blood using a portable device within 72 hours of admission to establish a personal baseline. If a new fall occurs and brain CT is considered necessary, a second biomarker measurement will be taken to inform decision-making about imaging. The goal is to determine whether this biomarker-based screening can safely guide imaging decisions and improve timely detection of intracranial hemorrhages in a population with variable biomarker levels. The trial focuses on blood sampling as the primary intervention, with enrollment limited to a specific hospital setting in Riom, France.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Hospitalized patients aged 75 years and older, cared for in the short-stay geriatric unit at Guy Thomas Hospital in Riom
* Recurrent fallers (more than one fall per week)
* Informed consent from the patient or their designated representative for patients unable to write but capable of understanding and consenting to participate in the study
* Enrollment in a Social Security health insurance scheme

Exclusion Criteria:

* Fall occurring before the reference biomarker measurement
* Presence of an intracranial hemorrhage confirmed by CT scan at admission
* Ischemic or hemorrhagic stroke
* Inability to perform the two blood samples required by the protocol due to very limited venous access
* End-of-life situation
* Adults under legal protection (guardianship, curatorship, deprivation of liberty, or judicial protection)

Where it's running

• Ch de Riom
  Riom, France Recruiting

Study contacts

• Principal investigator: Clément Lahaye — University Hospital, Clermont-Ferrand
• Study coordinator: Lise Laclautre
• Email: promo_interne_drci@chu-clermontferrand.fr
• Phone: +33473751195

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.