Home-based screening for undiagnosed heart failure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates a stepwise multimodal home-based screening strategy using rapid point-of-care testing to detect undiagnosed heart failure in high-risk patients. It compares this approach to usual care to determine if it increases the diagnosis of heart failure within six months and leads to more patients receiving guideline-directed medical therapy. The study also evaluates the long-term impact of earlier diagnosis on hospitalizations, mortality, functional capacity, quality of life, and healthcare costs over one, two, and five years.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Age ≥40 years, and at least one of the following symptoms of HF, and at least two risk factors for HF:

Symptoms

* Dyspnoea on exertion
* Dyspnoea at rest
* Orthopnoea
* Paroxysmal nocturnal dyspnoea
* Reduced exercise tolerance, increased time to recover after exercise
* Fatigue, tiredness
* Ankle swelling

Risk factors

* Diabetes (type 1 or type 2)
* Coronary artery disease (myocardial infarction or coronary artery bypass grafting or percutaneous coronary intervention)
* Persistent or permanent atrial fibrillation (not paroxysmal atrial fibrillation)
* Previous ischemic or embolic stroke
* Peripheral arterial disease (previous surgical or percutaneous revascularisation)
* Chronic kidney disease
* Regular loop diuretic use (any dose at any dosing interval) for \>30 days
* COPD (diagnosis by respiratory physician, radiological emphysema or treatment with advocated COPD therapy)

Exclusion Criteria:

* Previous diagnosis of HF
* Previous renal replacement therapy
* Inability to comply with study procedures or provide informed consent

Where it's running

• Uppsala Akademiska Hospital
  Uppsala, Sweden Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.