Home-based remote ischemic conditioning for people with spinal cord injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot randomized intervention enrolls adults with spinal cord injury to complete a 2-day baseline assessment, a 6-week home-based remote ischemic conditioning (RIC) intervention, and a 2-day post-intervention assessment. Participants are randomized to one of three groups: high-dose RIC using a standard blood pressure cuff, high-dose RIC using an automated blood flow restriction cuff, or low-dose RIC using a standard blood pressure cuff, with 30 home sessions delivered over six weeks. The trial collects cardiometabolic outcome measures and documents feasibility, adherence, barriers, and facilitators to implementing RIC in the home. Results will inform outcome selection and design for a larger efficacy trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 18 years of age or older
* Diagnosis of SCI
* Live within the community (not nursing facility)
* Not actively engaged in physical activity for exercise
* Not having the ability to participate in physical activity due to physical capacity or environmental barriers
* Medically stable
* Ability to obtain physician approval to participate in the study
* Willingness to participate in a 2-day initial assessment visit at research testing location, 30 intervention sessions conducted independently by the participant or caregivers, 2-day post intervention assessment visit at research testing location.

Exclusion Criteria:

* Medically unstable
* Have had a heart-related condition within the past year
* Have had a blood clot in the past year
* Have a stage 3 or 4 pressure injury
* Have taken blood thinners in the past year
* Have had surgery in the past year
* Have uncontrolled hypertension
* Have peripheral artery disease
* Have Complex Regional Pain Syndrome (CRPS) in both arms
* Have had nerve or tendon transfers in the arms in the past year
* Have lymphedema in the arms
* Have recent acute illness or injury (within the past 3 months)
* Currently pregnant
* Enrolled in another clinical trial
* Are taking GLP-1 medications
* Unable to provide consent
* Currently engaged in physical activity for exercise

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Kerri A Morgan, PhD — Washington University School of Medicine - Program in Occupational Therapy
• Study coordinator: Kerri A Morgan, PhD
• Email: morgank@wustl.edu
• Phone: 314-286-1659

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.