Home-based HIV prevention program evaluation

Hybrid Evaluation of the Implementation and Effectiveness of Home-based HIV Pre-exposure Prophylaxis Monitoring in King County, Washington

NA · University of Washington · NCT05856942

This study is testing a new home-based program that helps people at risk for HIV use a prevention medication more effectively by allowing them to collect their own samples and have virtual check-ins with healthcare providers.

Quick facts

PhaseNA
Study typeInterventional
Enrollment458 (estimated)
Ages18 Years and up
SexAll
SponsorUniversity of Washington (other)
Locations1 site (Seattle, Washington)
Trial IDNCT05856942 on ClinicalTrials.gov

What this trial studies

This study aims to implement and evaluate a home-based PrEP (HB-PrEP) monitoring system that allows participants to self-collect blood and extragenital specimens at home, followed by telehealth consultations. The program will be integrated into a large urban sexual health clinic in King County, focusing on improving PrEP retention rates among individuals at risk for HIV. By comparing the HB-PrEP approach to standard in-clinic monitoring, the study seeks to identify factors influencing the implementation and effectiveness of this innovative care model.

Who should consider this trial

Good fit: Ideal candidates for this study are individuals aged 18 and older who are eligible for PrEP and reside in Washington State.

Not a fit: Patients who have had recent high-risk HIV exposure or those without access to necessary technology for participation may not benefit from this study.

Why it matters

Potential benefit: If successful, this program could significantly improve access to HIV prevention methods and increase retention in PrEP care for at-risk populations.

How similar studies have performed: Previous studies have shown promise in similar home-based health interventions, suggesting potential for success in this novel approach to PrEP monitoring.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Must be eligible to receive PrEP per PHSKC criteria
* Age ≥18 years
* Washington State resident
* Ability to speak, understand and read/write in English or Spanish
* Willing to provide contact information
* Willing to be randomized and adhere to study procedures

Exclusion Criteria:

* Recent (\<4 weeks) "high risk" HIV exposure while off PrEP or symptoms of acute HIV
* No mailing address to receive sampling kits
* No working telephone number
* No smartphone or other device with internet access
* History of a bleeding disorder, or current or recent (≤7 days) use of anticoagulant medications
* Pregnancy

Where this trial is running

Seattle, Washington

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: HIV Prevention, Pre-exposure Prophylaxis, STI, Implementation science, PrEP, Screening, Telehealth

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.