Home-based exercise and behavioral training to reduce frailty before lung transplant
Official title: An eXercise-based Frailty Intervention in Lung Transplantation (XFIT): A Phase Ib Clinical Trial Focused on Establishing Safety
Run by University of California, San Francisco · NCT06960421 · Data updated 2026-11-12
A remote 8-week exercise and motivation program is tested in adults awaiting lung transplant to see if it is safe and helpful for frailty and physical function.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 70 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 4 sites (San Francisco, California and 3 other locations) |
| Status | Recruiting |
| Started | October 22, 2026 |
| Main results expected | July 1, 2029 |
| Study ends | July 1, 2029 |
| Registry record updated | October 16, 2026 |
| Trial ID | NCT06960421 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Lung transplant candidates aged 18 to 65 (Group 1) or 18 to 75 (Group 2) who speak English or Spanish, have mild to moderate oxygen needs during walking, and a baseline frailty score (SPPB) of 10 or less.
✕Probably not a fit
Patients with severe comorbidities or safety concerns incompatible with unsupervised home exercise may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized study tests an 8-week telehealth-delivered exercise and behavioral training program for lung transplant candidates with frailty. Participants are assigned to either the XFIT program or enhanced standard of care and receive weekly one-on-one sessions via video to exercise and address barriers to activity. Primary goal is safety, with secondary aims including feasibility and acceptability, changes in frailty, 6-minute walk distance, and patient-reported outcomes. The study plans to enroll 70 diverse participants across multiple sites and will use remote sessions led by an exercise physiology expert. Results will inform larger-scale interventions in solid organ transplantation.
Why it matters
Potential benefit: If successful, the program could improve physical function and frailty status, potentially supporting better transplant readiness.
How similar studies have gone: Prevailing data on remote prehabilitation in solid organ transplantation are limited; this is among the first targeted trials in this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Group 1 Inclusion Criteria: * Age 18 - 65 years * Lung Transplant Candidates * Speaks English or Spanish * ≤ 8LPM O2 on 6MWT * SPPB score ≤ 10 Exclusion Criteria: * Lives Alone * BMI \< 18.0 kg/m2 * Engaged in clinical pulmonary rehabilitation program * Severe pHTN (RHC mPAP ≥ 30 mmHg or TTE PASP ≥ 60mmHg or moderately/severely reduced RV systolic function on TTE * Deemed unsafe by site PI Group 2 Inclusion Criteria: * Age 18 - 75 years * Speaks English or Spanish * ≤ 15LPM O2 on 6MWT * SPPB score ≤ 10 Exclusion Criteria: * Lives Alone * BMI \< 18.0 kg/m2 * Engaged in clinical pulmonary rehabilitation program * Severely reduced RV systolic function on TTE * Deemed unsafe by site PI
Where it's running
-
University of California,San Francisco
San Francisco, California, United States Recruiting -
Columbia University
New York, New York, United States Not yet recruiting -
University of North Carolina
Chapel Hill, North Carolina, United States Not yet recruiting -
University of Pennsylvania
Philadelphia, Pennsylvania, United States Not yet recruiting
Study contacts
- Principal investigator: Jonathan Singer, MD, MS — University of California, San Francisco
- Study coordinator: Legna Betancourt
- Email: legna.betancourt@ucsf.edu
- Phone: 415-476-8073
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.