High-risk plaque on photon-counting CT and future coronary events

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center observational study enrolls adults with acute or stable coronary syndromes who are planned for invasive angiography and OCT. Participants undergo a contrast-enhanced photon-counting detector CT to identify high-risk plaque features, and within about 30 days have invasive angiography with OCT for cross-sectional comparison. The study assesses whether PCCT-detected high-risk plaque predicts major adverse cardiovascular events or revascularization during follow-up, and compares PCCT findings with OCT results using blinded core laboratories. Data from the imaging modalities will be analyzed to evaluate diagnostic performance relative to clinical outcomes. The overall goal is to determine if non-invasive PCCT can help identify patients at higher risk for future events.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Scheduled for clinically indicated, non-emergent invasive coronary angiography
* Provision of written informed consent and willingness to comply with long-term follow-up

Exclusion Criteria:

* Estimated glomerular filtration rate \<45 mL/min/1.73 m²
* Known allergy to iodinated contrast media
* Pregnancy or breastfeeding
* Persistent atrial fibrillation or other arrhythmia precluding adequate ECG-gated CT acquisition
* Body mass index \>40 kg/m²
* Target vessel with a previously implanted stent
* Life expectancy \<2 years or any condition that, in the opinion of the investigator, makes follow-up unlikely or participation inappropriate

Where it's running

• Beijing Chaoyang Hospital，Capital Medical University, Beijing
  Beijing, China, China Recruiting

Study contacts

• Study coordinator: Bin Tu, MD.PhD
• Email: dr_bintu@163.com
• Phone: +8618810682692

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.