Laryngopharyngeal injuries after breathing tube placement during general anesthesia
Incidence,Perioperative Risk Factors and Prognosis Associated With Laryngopharyngea Injury After Endotracheal Intubation Under General Anesthesia：A Retrospective Study
This project sees how often and why people who had a breathing tube during general anesthesia developed hoarseness or other throat problems after non-ear–nose–throat surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Sex | All |
| Sponsor | Zhejiang University Academic / other |
| Locations | 2 sites (Hangzhou, Zhejiang and 1 other locations) |
| Trial ID | NCT07359586 on ClinicalTrials.gov |
What this trial studies
This retrospective study reviews patients at the First Affiliated Hospital, Zhejiang University School of Medicine who underwent tracheal intubation under general anesthesia between October 1, 2015 and September 30, 2025 and later required otolaryngology consultation for laryngopharyngeal complaints. Patient data will be extracted from the anesthesia information management system and electronic medical records, and telephone follow-up will be used to document longer-term outcomes. The primary outcome is identification of risk factors for postoperative hoarseness, while secondary outcomes include the incidence and severity of vocal fold injury and factors related to prognosis. Findings will be used to characterize which perioperative practices and patient features are associated with worse throat or voice outcomes.
Who should consider this trial
Good fit: Ideal candidates are patients who had general anesthesia with tracheal intubation at the First Affiliated Hospital, Zhejiang University School of Medicine between October 2015 and September 2025 and required an otolaryngology consult for postoperative laryngopharyngeal complaints after non-ENT surgery.
Not a fit: Patients with preexisting laryngopharyngeal lesions, prior or postoperative tracheotomy, incomplete medical records, or multiple surgeries where the causative episode cannot be identified are unlikely to benefit from this retrospective analysis.
Why it matters
Potential benefit: If successful, the findings could help clinicians identify patients at higher risk of voice and throat injury and guide changes in intubation and perioperative care to reduce those complications.
How similar studies have performed: Prior observational studies have documented rates and some risk factors for post‑intubation hoarseness and vocal fold injury, but findings vary and additional large institutional series help refine risk estimates.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who underwent general anesthesia with tracheal intubation at the First Affiliated Hospital of Zhejiang University School of Medicine between October 2015 and September 2025 * Patients who required otolaryngological consultation due to laryngopharyngeal complaints (including hoarseness, sore throat, cough, choking on drinking water, etc.) postoperatively * The surgical type was non-otolaryngological surgery Exclusion Criteria: * Patients with a history of laryngopharyngeal lesions (e.g., granuloma, polyp, tumour, vocal cord paralysis * Patients with a preexisting tracheotomy * Patients requiring postoperative tracheotomy * Patients with incomplete medical records * Patients who underwent multiple surgeries but for whom the specific surgical episode responsible for the laryngopharyngeal complaints could not be identified
Where this trial is running
Hangzhou, Zhejiang and 1 other locations
- he First Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (Completed)
- The First Affiliated Hospital, Zhejiang University School of Medicine — Hangzhou, Zhejiang, China (Recruiting)
Study contacts
- Principal investigator: Diansan Su — Zhejiang University
- Study coordinator: Diansan Su
- Email: diansansu@yahoo.com
- Phone: +8618616514088
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.