Clinical trial Recruiting at 1 site Observational Ages 18 and up

Hepatic Vein Filling Fraction vs TAPSE to Check Right Heart Function in Mechanically Ventilated ICU Patients

Official title: Diagnostic Accuracy of Hepatic Vein Systolic Filling Fraction Compared With TAPSE for Assessment of Right Ventricular Systolic Function in Mechanically Ventilated Critically Ill Patients

Run by Menoufia University · NCT07732114 · Data updated 2026-11-12

We’re testing if the hepatic vein systolic filling fraction can reliably show how well the right side of the heart is pumping in adults on breathing machines in the ICU.

More Critically Ill Intensive Care Unit Patients trials

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment115 (estimated)
SponsorMenoufia University
Academic / other
Locations1 site (Alexandria, Shebin El-Kom)
StatusRecruiting
StartedSeptember 10, 2026
Main results expectedJuly 1, 2027
Study endsJuly 15, 2027
Registry record updatedSeptember 10, 2026
Trial IDNCT07732114 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (18+) in the ICU who are mechanically ventilated and have adequate acoustic windows for TAPSE and hepatic vein Doppler assessment.

Probably not a fit

Patients with poor acoustic windows or inability to obtain reliable hepatic vein Doppler or TAPSE measurements may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study comparing a non-invasive hepatic vein Doppler measure, the systolic filling fraction, with the standard TAPSE measurement to assess right ventricular systolic function in mechanically ventilated critically ill adults. Researchers will enroll eligible ICU patients and perform Doppler ultrasound assessments to evaluate the diagnostic accuracy of hepatic vein SFF against TAPSE. The goal is to determine whether the hepatic vein signal can serve as a real-time indicator of RV function in this high-risk population. No interventional treatment is involved; the study observes existing clinical data and imaging results. Findings could clarify if hepatic vein SFF is a valid alternative or adjunct to TAPSE in the ICU setting.

Why it matters

Potential benefit: If successful, hepatic vein SFF could provide a quick, non-invasive way to monitor RV function at the bedside.

How similar studies have gone: Previous work has explored hepatic vein Doppler as a diagnostic tool, but direct comparisons with TAPSE in mechanically ventilated ICU patients are limited and need confirmation.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Age ≥ 18 years.
2. Mechanically ventilated patients
3. Patients in whom transthoracic echocardiography (TTE) can be performed Adequate acoustic window to measure TAPSE.
4. Patients in whom hepatic vein Doppler assessment is feasible Adequate subcostal view for Doppler sampling.

Exclusion Criteria:

Where it's running

  • Menoufia University
    Alexandria, Shebin El-Kom, Egypt
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.