Hepatic Vein Filling Fraction vs TAPSE to Check Right Heart Function in Mechanically Ventilated ICU Patients
Official title: Diagnostic Accuracy of Hepatic Vein Systolic Filling Fraction Compared With TAPSE for Assessment of Right Ventricular Systolic Function in Mechanically Ventilated Critically Ill Patients
Run by Menoufia University · NCT07732114 · Data updated 2026-11-12
We’re testing if the hepatic vein systolic filling fraction can reliably show how well the right side of the heart is pumping in adults on breathing machines in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 115 (estimated) |
| Sponsor | Menoufia University Academic / other |
| Locations | 1 site (Alexandria, Shebin El-Kom) |
| Status | Recruiting |
| Started | September 10, 2026 |
| Main results expected | July 1, 2027 |
| Study ends | July 15, 2027 |
| Registry record updated | September 10, 2026 |
| Trial ID | NCT07732114 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) in the ICU who are mechanically ventilated and have adequate acoustic windows for TAPSE and hepatic vein Doppler assessment.
✕Probably not a fit
Patients with poor acoustic windows or inability to obtain reliable hepatic vein Doppler or TAPSE measurements may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective observational study comparing a non-invasive hepatic vein Doppler measure, the systolic filling fraction, with the standard TAPSE measurement to assess right ventricular systolic function in mechanically ventilated critically ill adults. Researchers will enroll eligible ICU patients and perform Doppler ultrasound assessments to evaluate the diagnostic accuracy of hepatic vein SFF against TAPSE. The goal is to determine whether the hepatic vein signal can serve as a real-time indicator of RV function in this high-risk population. No interventional treatment is involved; the study observes existing clinical data and imaging results. Findings could clarify if hepatic vein SFF is a valid alternative or adjunct to TAPSE in the ICU setting.
Why it matters
Potential benefit: If successful, hepatic vein SFF could provide a quick, non-invasive way to monitor RV function at the bedside.
How similar studies have gone: Previous work has explored hepatic vein Doppler as a diagnostic tool, but direct comparisons with TAPSE in mechanically ventilated ICU patients are limited and need confirmation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years. 2. Mechanically ventilated patients 3. Patients in whom transthoracic echocardiography (TTE) can be performed Adequate acoustic window to measure TAPSE. 4. Patients in whom hepatic vein Doppler assessment is feasible Adequate subcostal view for Doppler sampling. Exclusion Criteria:
Where it's running
-
Menoufia University
Alexandria, Shebin El-Kom, Egypt Recruiting
Study contacts
- Study coordinator: Nevine Mostafa Soliman, Ass. Prof.
- Email: mostafanevine@gmail.com
- Phone: +201128861471
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.