Using blood tests to identify bacteria in ICU patients with sepsis
Blood DdPCR for Early Identification and Dynamic Surveillance of Pathogenic Bacteria in ICU Septic Patients: a Single-centre, Prospective, Observational Study
This study is testing a new blood test to see if it can help doctors find harmful bacteria in ICU patients with sepsis so they can better track infections and improve patient care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Academic / other |
| Locations | 1 site (Wuhan) |
| Trial ID | NCT06791889 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of droplet digital PCR (ddPCR) for detecting pathogenic bacteria in patients diagnosed with sepsis in the ICU. Patients will be monitored for bacterial nucleic acid loads in their blood at various time points until they are either discharged or 28-30 days have passed. The study seeks to establish a correlation between the types and amounts of bacteria present and the patients' clinical outcomes. By doing so, it hopes to improve early identification and ongoing surveillance of infections in critically ill patients.
Who should consider this trial
Good fit: Ideal candidates are adults admitted to the ICU with a first diagnosis of sepsis.
Not a fit: Patients under 18 years old or those who do not meet the Sepsis 3.0 diagnostic criteria will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to faster diagnosis and better management of sepsis in ICU patients.
How similar studies have performed: While similar studies using ddPCR for pathogen detection have shown promise, this specific approach in ICU sepsis patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with first diagnosis of sepsis after ICU admission Exclusion Criteria: * Age under 18 years * Do not meet Sepsis 3.0 diagnostic criteria * Refusal to sign informed consent
Where this trial is running
Wuhan
- Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, China (Recruiting)
Study contacts
- Study coordinator: You Shang, prof.
- Email: you_shanghust@163.com
- Phone: 008602785351606
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.